Comparison of Calcitonin Gene Related Peptide Level between Children with Dilated Cardiomyopathy and Control Group

Background: Dilated cardiomyopathy is revealed with left ventricular dilatation and systolic dysfunction.

Objectives: This study aimed to compare the children with dilated cardiomyopathy and control group regarding the level of Calcitonin Gene Related Peptide (CGRP) and its relationship with echocardiography findings

Patients and Methods: This case-control study was conducted on 37 children with dilated cardiomyopathy and free of any clinical symptoms and 37 healthy age- and sex-matched children referring to Ali-e-Asghar and Ali Ebne Abitaleb hospitals in Zahedan, Iran. After taking history, echocardiography was performed for both groups. The data were analyzed using the SPSS statistical software and appropriate statistical tests.

Results: The two groups were significantly different regarding most of the echocardiographic parameters (P < 0.05). Also, a significant difference was found between the two groups concerning the mean CGRP levels (P = 0.001). Among echocardiographic parameters, CGRP was directly related to Interventricular Septal dimension in Systole (IVSS) (P = 0.022, R = 0.375). However, no significant relationship was observed between CGRP level and Ross classification.

Conclusions: The findings of this study showed an increase in CGRP serum levels in the case group. Besides, a direct correlation was observed between CGRP level and IVSS.