Image Credit:J Cell Mol Anesth
Outline
The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG
Authors
1,*, mahdi shadnoush2, alireza jahangirifard3, Mahnoosh Foroughi4, Hossein Ali Jelveh Moghaddam5, Ali Dabbagh6Abstract
Introduction: a number of preventive or therapeutic strategies have been proposed to compensate for the inflammatory process during adult cardiac surgeries; none have been considered definitive. 1,25 (OH)2 Vitamin D3 is among the so called physiologic hormones with immunomodulatory effects. This study assessed the effect of oral Vitamin D on serum levels of IL-1, IL-6 and TNF-? in adult CABG.Materials and methods: in a double blind placebo controlled clinical trial, 80 patients entered the study after qualifying study criteria; being divided to Vitamin D and placebo groups, serum cytokines (IL-1, IL-6, and TNF-?) were measured preoperatively and also during the 1st day after the operation.Results: serum TNF-? levels were similar in the 2 groups; however, postoperative levels of IL-1 and IL-6 were significantly lower in Vitamin D group.Conclusion: the current study demonstrated that oral Vitamin D supplements could augment immunomodulatory effects in adult patients undergoing cardiac surgical procedures (mainly CABG).Keywords:?Vitamin D, Cardiopulmonary Bypass, Cytokine, Inflammation
Highlights
References
- 1.References are in the PDF file of the article.
Copyright
© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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