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Journal of Cellular & Molecular Anesthesia

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v3i3.19258

The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG

Author(s):
Kamal FaniKamal FaniKamal Fani ORCID1,*, mahdi shadnoushmahdi shadnoushmahdi shadnoush ORCID2, alireza jahangirifardalireza jahangirifard3, Mahnoosh ForoughiMahnoosh ForoughiMahnoosh Foroughi ORCID4, Hossein Ali Jelveh MoghaddamHossein Ali Jelveh Moghaddam5, Ali DabbaghAli DabbaghAli Dabbagh ORCID6
1MD, Assistant Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center, Cardiac Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2MD, PhD, Associate Professor; Department of Clinical Nutrition, Faculty of Nutrition & Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3MD, Associate Professor, Fellowship in Cardiac Anesthesia, Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
4MD, Associate Professor, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5MD, Assistant Professor, Anesthesiology Research Center, Cardiac Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6Professor of Cardiac Anesthesia; Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: MD, Assistant Professor, Fellowship in Cardiac Anesthesiology, Anesthesiology Research Center, Cardiac Anesthesiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran Email: [email protected]
Journal of Cellular & Molecular Anesthesia:Vol. 3, issue 3; e150279
Published online:Nov 04, 2018
Article type:Original Articles
How to Cite:Fani K, shadnoush M, jahangirifard A, Foroughi M, Jelveh Moghaddam HA, et al. The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG. J Cell Mol Anesth. 2018;3(3):e150279. doi: https://doi.org/10.22037/jcma.v3i3.19258

Abstract

Introduction: a number of preventive or therapeutic strategies have been proposed to compensate for the inflammatory process during adult cardiac surgeries; none have been considered definitive. 1,25 (OH)2 Vitamin D3 is among the so called physiologic hormones with immunomodulatory effects. This study assessed the effect of oral Vitamin D on serum levels of IL-1, IL-6 and TNF-? in adult CABG.Materials and methods: in a double blind placebo controlled clinical trial, 80 patients entered the study after qualifying study criteria; being divided to Vitamin D and placebo groups, serum cytokines (IL-1, IL-6, and TNF-?) were measured preoperatively and also during the 1st day after the operation.Results: serum TNF-? levels were similar in the 2 groups; however, postoperative levels of IL-1 and IL-6 were significantly lower in Vitamin D group.Conclusion: the current study demonstrated that oral Vitamin D supplements could augment immunomodulatory effects in adult patients undergoing cardiac surgical procedures (mainly CABG).Keywords:?Vitamin D, Cardiopulmonary Bypass, Cytokine, Inflammation

Keywords
1
25-Dihydroxyvitamin D3
cytokine
coronary artery bypass graft
inflammation

References

  • 1.
    References are in the PDF file of the article.

Copyright

© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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