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International Cardiovascular Research Journal
An annual journal in scientific affiliation with the Cardiovascular Research Center, Shiraz University of Medical Sciences
e-ISSN 2251-9149
p-ISSN 2251-9130
Image Credit:Int Cardiovasc Res J
Outline
Roles of Serum Parathyroid Hormone and Vitamin D Levels in Severity of Coronary Artery Disease and Left Ventricular Systolic Function
Authors
Arsalan Salari
1, Arash Mazouri1, Yasaman Borghei1, Samaneh Karami1, Jalal Kheirkhah1, Fardin Mirbolouk1,*
1, Arash Mazouri1, Yasaman Borghei1, Samaneh Karami1, Jalal Kheirkhah1, Fardin Mirbolouk1,*1Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IR Iran
*Corresponding Author: Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Cellphone: +98- 9111313400, Email: dr.mirbolouk@gmail.com.dr.mirbolouk@gmail.com
Published online:Dec 25, 2023
Article type:Research Article
How to Cite:Salari A, Mazouri A, Borghei Y, Karami S, Kheirkhah J, et al. Roles of Serum Parathyroid Hormone and Vitamin D Levels in Severity of Coronary Artery Disease and Left Ventricular Systolic Function. Int Cardiovasc Res J. 2023;17(2):e139878. doi:
Abstract
Background: Vitamin D and parathyroid hormone (PTH) are related but impact cardiovascular functions differently.
Objectives: This study investigated the roles of PTH and vitamin D serum levels in the severity of coronary artery disease and left ventricular systolic function (LVSF).
Methods: This cross-sectional study was conducted on 271 participants who underwent elective coronary angiography at Dr. Heshmat Hospital, selected by convenience sampling over four months. 25-hydroxyvitamin D (25 (OH) D) and PTH levels were obtained from patients’ blood samples. Vitamin D levels were categorized into three categories. The SYNTAX score was used to evaluate the severity of coronary artery disease (CAD), classified across three categories. The chi-squared test, independent samples t-test, and multivariable logistic regression were used for statistical analysis. Data were analyzed by SPSS ver.21.
Results: Diabetes, hypertension, dyslipidemia, and lower vitamin D levels were independent variables affecting patients’ high-risk conditions. The highest SYNTAX score was in patients with vitamin D deficiency (P < 0.001). Patients with different ejection fractions did not have statistically significant differences in vitamin D (25.38 ± 14.23) and PTH levels (66.62 ± 17.39) (P = 0.4). The severity of CAD in patients with PTH > 40 was higher than in patients with PTH ≤ 40, but this was not statistically significant (P = 0.06).
Conclusion: Our results showed an inverse relation between CAD and vitamin D. However, the CAD risk did not change with PTH levels.
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References
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Copyright
© 2023, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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