A Comparative Effect of Intravenous Pethidine vs Sufentanil on Attenuation of Cardiovascular Responses to Laryngoscopy and Tracheal Intubation: a Randomized Double-Blind Placebo Controlled Trial Study

Background: The study was undertaken to compare the effects of small doses of sufentanil or pethidine on cardiovascular
changes induced by tracheal intubation.
Patients and Methods: Sixty American Soceity of Anesthesiology (ASA) physical status I-II patients, scheduled
for elective abdominal surgery under general anesthesia, randomly allocated in a double- blind fashion to receive
an intravenous bolus of either sufentanil 0.1 μg/kg (Group S, n = 30) or pethidine 1.5 mg/kg (Group P, n = 30) for
induction of anesthesia. The heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP),
and mean arterial pressure (MAP) were measured before induction of anaesthesia (baseline), at 1-min intervals
for 3 min after the induction of anesthesia, at 1, 3, 5, and 7 min after start of laryngoscopy.
Results: No significant differences in SAP, DAP, and MAP were observed between the two groups. Heart rate
significantly increased 2 and 3 minutes after induction of anesthesia and 1 minute after intubation in group P
compared with group S (P<0.01). However, the numbers of patients who developed a heart rate increase more
than 20% of basal value were not different between two groups. At the end of the study period, systolic, diastolic,
and mean arterial pressure slightly decreased from preinduction values that was transient and did not require
treatment.
Conclusions: If adequate timing in opioid administration is warranted according to the time to peak effect of
each opioid drug, small doses of sufentanil or pethidine exert similar effect in controlling the inotropic response
induced by the laryngoscopy and tracheal intubation.