Journal of Cellular & Molecular Anesthesia
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Comparison of Two Methods of Bolus and Infusion of Tranexamic Acid in Reduction of Blood Loss in Total Knee Arthroplasty
Mohammadreza Moshari1,*, Bahman Malek1, Mohammadreza Minator Sajjadi1, Maryam Vosoughian
2, Mastaneh Dahi Taleghani3, Mahshid Ghasemi1, Razieh Shekari4Abstract
AbstractBackground:?So far, many studies?have been performed?to determine the optimal dose and regimen of?tranexamic acid to reduce?preoperative and postoperative blood loss in primary total knee?arthroplasty. In the present?study, two different methods of administration (bolus and infusion),?were?compared.Materials and Methods:?Forty patients were randomized in?the two groups?(A and B)?of 20 patients each. All patients received 500 mg?tranexamic acid before?inflation of?tourniquet. Group A (mean age,?64? 6.1 years) received 500 mg tranexamic acid?10?minutes before?loosening of?tourniquet and?group B (mean age,?63.5 ? 7.7 years) received 500 mg?tranexamic acid?through?IV infusion during 6 hours from the?time of tourniquet loosening (total dose of TA,?1 g in both groups). Intraoperative blood loss,postoperative drainage (in 6 and 12 hours), blood transfusion (in 48 hours),?and decrease in?hematocrit?and?hemoglobin?(6 and 12 hours later),?were compared between?the?two groups.Results:?The patients in group B had?lower?intra- and postoperative?blood loss?in 6 and 12?hours and also had?lower decrease in?hemoglobin,?and?their?packed cell transfusion rate was significantly?lower compared to?the?group A.Conclusion:?The findings of this?study?indicated?that infusion administration of tranexamic acid in?primary total knee arthroplasty,?was more effective?in the reduction of?perioperative blood loss?as well as?need?for blood transfusion in 48 hours.
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© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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