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Journal of Cellular & Molecular Anesthesia

e-ISSN 2476-5120
p-ISSN 2538-2462
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https://doi.org/10.22037/jcma.v4i3.28189

The role of connective tissue genomics in ascending aortic dissection: A case of Marfan syndrome

Authors

Firoozeh MadadiFiroozeh Madadi ORCID1,*, manouchehr hekmat2, Zahra Ansari AvalZahra Ansari Aval ORCID3, Abdolhamid Bagheri4, Kamal FaniKamal Fani ORCID5, Mohammad Hosein Ghanbarpour6, maryam hamidzad7, Mehrubon Murodov8, Ali DabbaghAli Dabbagh ORCID9
1MD, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2MD, Associate Professor, Department of Cardiac Surgery, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3MD, Assistant Professor, Department of Cardiac Surgery, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4MD, Assistant Professor, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Assistant Professor of Cardiac Anesthesia, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6MD, Assistant Professor, Anesthesiology Department, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
7MD, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8MD, Republican Scientific Center of Cardiovascular Surgery, Dushanbe, Tajikistan
9Professor of Cardiac Anesthesia, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: MD, Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Email: [email protected]
Journal of Cellular & Molecular Anesthesia:Vol. 4, issue 3; e149588
Published online:Jan 28, 2020
Article type:Brief Communications
How to Cite:Madadi F, hekmat M, Ansari Aval Z, Bagheri A, Fani K, et al. The role of connective tissue genomics in ascending aortic dissection: A case of Marfan syndrome. J Cell Mol Anesth. 2019;4(3):e149588. doi: https://doi.org/10.22037/jcma.v4i3.28189

Abstract

Background: Aortic dissection is a rare yet life threating condition with some already discovered risk factors namely hypertension, connective tissue disorders such as Marfan syndrome (MFS), cocaine abuse and cigarette smoking.Case report: In this article we would like to present a case of MFS who presented with severe chest pain and undergone Bentall surgery due to aortic dissection and aneurysm.Conclusion: Although many risk factors and preventive measures are already investigated, there is no definite method to avoid its occurrence in genetically predisposed patients such as MFS. Patient-specific models utilizing embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) may offer some advantages.

KeywordsMarfan syndrome - Aortic dissection - iPSC - cocaine

References

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    References are in the PDF file of the article.

Copyright

© 2019, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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