Effect of Dexmedetomidine on Transcription Factors and Inflammatory Cytokines in Elective Aortic Aneurysm Repair Surgery

Faranak Behnaz; ronak karbalaeifar; Azita Chegini; Gholamreza Mohseni; Samad Valizadeh

doi:10.22037/jcma.v5i3.30882

Journal of Cellular & Molecular Anesthesia

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https://doi.org/10.22037/jcma.v5i3.30882

Effect of Dexmedetomidine on Transcription Factors and Inflammatory Cytokines in Elective Aortic Aneurysm Repair Surgery

Author(s):

Faranak Behnaz

^1,*,

ronak karbalaeifar²,

Azita Chegini

³,

Gholamreza Mohseni

⁴,

Samad Valizadeh⁵

1Assistant professor of anesthesiology, Anesthesiology research center, Shahid Beheshti university of medical sciences, Tehran, Iran

2Resident of anesthesiology, Anesthesiology research center, Shahid Beheshti university of medical sciences, Tehran, Iran

3Assistant professor of anesthesiology, Blood transfusion research center, High Institute for Research and education in transfusion medicine, Tehran, Iran

4Associated professor of anesthesiology, Anesthesiology research center, Shahid Beheshti university of medical sciences, Tehran, Iran

5Blood transfusion research center, High Institute for Research and education in transfusion medicine, Tehran, Iran

Journal of Cellular & Molecular Anesthesia:Vol. 5, issue 3; e149629

Published online:Jul 23, 2020

Article type:Original Articles

How to Cite:Behnaz F, karbalaeifar R, Chegini A, Mohseni G, Valizadeh S. Effect of Dexmedetomidine on Transcription Factors and Inflammatory Cytokines in Elective Aortic Aneurysm Repair Surgery. J Cell Mol Anesth. 2020;5(3):e149629. doi: https://doi.org/10.22037/jcma.v5i3.30882

Abstract

Background: Aortic clamping during abdominal aortic aneurysm repair surgery leads to complications such as systemic inflammatory response (SIRS) and dysfunction in various vital organs. This study aimed to investigate the effect of dexmedetomidine infusion on transcription factors and inflammatory cytokines during elective open abdominal aortic aneurysm repair surgery. Materials and Methods: A prospective, clinical trial performed on patients with abdominal aortic aneurysm surgery, which were divided into two groups (dexmedetomidine, 8 patients and control, 12 patients). Demographic characteristics, biochemical laboratory variables, fluid and blood transfusions during surgery, and levels of inflammatory cytokines and expression of inflammatory genes were evaluated and compared in both groups. Results: There were no significant differences between the two groups regarding demographic characteristics, biochemical laboratory variables, fluids, and blood transfusions during surgery (P> 0.05). The level of inflammatory cytokines and the expression of inflammatory genes in both groups decreased significantly after surgery (P <0.05). However, the level of inflammatory cytokines and the expression of inflammatory genes in the dexmedetomidine group were significantly lower at the end of the surgery (P <0.05). Conclusion: In abdominal aortic aneurysm surgery, dexmedetomidine could significantly reduce complications of clamping during surgery, which may result in hemodynamic stability and prevent significant inflammatory response to surgical stress and organ damage following ischemia-reperfusion damage.

Keywords

Abdominal aortic aneurysm

inflammatory factors

transcription factors

blood transfusion

hemodynamics

clamping and de-clamping

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Author(s):

Faranak Behnaz:[PubMed][Scholar]
ronak karbalaeifar:[PubMed][Scholar]
Azita Chegini:[PubMed][Scholar]
Gholamreza Mohseni:[PubMed][Scholar]
Samad Valizadeh:[PubMed][Scholar]

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Effect of Dexmedetomidine on Transcription Factors and Inflammatory Cytokines in Elective Aortic Aneurysm Repair Surgery

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