Evaluation of the Neuroprotective Effect of Thiopental and Its Effect on Serum NSE Level in Neurocritical Care Patients
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Abstract
Background: This study aimed to evaluate the neuroprotective effect of thiopental and its effect on serum NSE levels in neurocritical care patients. Materials and Methods: Patients were divided into two groups (intervention and control). Thiopental administration as the intervention was started at a dose of 3-6 mg/Kg every 30 minutes and continued until 0.3-3 mg/Kg/hour. Sedation with fentanyl and midazolam as control was also performed in 35 patients. After three days, thiopental was discontinued. On the fifth day, the desired indicators were compared between the two groups. Results: On the third and fifth days, patients in the intervention group had a greater drop in serum NSE levels (P<0.05). Conclusion: The use of thiopental in patients undergoing neurosurgery transferred to the ICU can significantly reduce the NSE of these patients.
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© 2023, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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