Full Text
Full text is available in PDF
Jundishapur Journal of Microbiology
Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2008-4161
p-ISSN 2008-3645
Intralesional injections of metronidazole versus meglumine antimoniate for the treatment of cutaneous leishmaniasis
Authors
1Department of Dermatology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, mapar_m@yahoo.com, Iran
2Department of Dermatology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Iran
*Corresponding Author: Department of Dermatology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, mapar_m@yahoo.com, Iran. Email: mapar_m@yahoo.com
Published online:Apr 30, 2010
Article type:Research Article
Received:Jan 01, 2010
Accepted:Apr 01, 2010
How to Cite:Mapar MA, Omidian M, . Intralesional injections of metronidazole versus meglumine antimoniate for the treatment of cutaneous leishmaniasis. Jundishapur J Microbiol. 2010;3(2):. doi:
Abstract
Introduction and objective: Oral metronidazole is reported before as effective treatment of cutaneous leishmaniasis. The aim of the present study was to evaluate the efficacy of intralesional metronidazole injection versus intralesional meglumine antimoniate (Glucantim®) in the treatment of cutaneous leishmaniasis.
Materials and methods: The 36 patients with clinical and parasitologic diagnosis of cutaneous leishmaniasis participated in this study. The patients were randomly divided into two groups. Group one, 18 patients were treated with weekly intralesional of Glucantim injections, and group two, 18 patients were treated with weekly intralesional injections of metronidazole. Intralesional injections was administered enough to blanch the lesions surfaces (0.5-2ml for each lesion in both groups).
Results: Twenty eight patients completed the study. Sixteen patients in group one and 12 patients in group two. In group one, 13 patients recovered with eight injections (81%). and of group two, only three patients recovered with eight injections (16.6%). The pain of intralesional injections of metronidazole was much more than the Glucantim injections.
Conclusions: Intralesional metronidazole injections have little effect for the treatment of cutaneous leishmaniasis.
Highlights
Copyright
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
20
Nov
2010
A Comparative Study of Aminosidine Sulfate, Meglomine Antimoniate, Combination of both and Glucantime in Murine Leishmaniasis Treatment of Cutaneous Leishmaniasis, Caused by Leishmania tropica, with Topical Application of Paromomycin 20% in BALB-c Mice
Mohammad Shahidi Dadras,
Afshin Mirzaei,
Bahram Kazemi,
Leyla Nabai,
Ali Sharifian
Shahidi Dadras M, Mirzaei A, Kazemi B, Nabai L, Sharifian A. A Comparative Study of Aminosidine Sulfate, Meglomine Antimoniate, Combination of both and Glucantime in Murine Leishmaniasis Treatment of Cutaneous Leishmaniasis, Caused by Leishmania tropica, with Topical Application of Paromomycin 20% in BALB-c Mice. Iran J Pharm Res. 2022;6(3):e128334. doi: https://doi.org/10.22037/ijpr.2010.723
15
May
2014
Comparison Between Intralesional Meglumine Antimoniate and Combination of Trichloroacetic Acid 50% and Intralesional Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis: A Randomized Clinical Trial
Mohammad Ali Nilforoushzadeh,
Fariba Jaffary,
Roya Derakhshan,
Elaheh Haftbaradaran
Nilforoushzadeh MA, Jaffary F, Derakhshan R, Haftbaradaran E. Comparison Between Intralesional Meglumine Antimoniate and Combination of Trichloroacetic Acid 50% and Intralesional Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis: A Randomized Clinical Trial. J Skin Stem Cell. 2014;1(1):e16633. doi: https://doi.org/10.17795/jssc16633
1
Oct
2007
Therapeutic and Adverse Effects of Glucantime Used for Treatment of Cutaneous Leishmaniasis.
M Beheshti
Beheshti M. Therapeutic and Adverse Effects of Glucantime Used for Treatment of Cutaneous Leishmaniasis.. Shiraz E-Med J. 2007;8(4):. doi:
6
Sep
2021
Comparative Assessment of Topical Glucantime® Injection Plus Cryotherapy and Cryotherapy Alone for Treatment of Anthroponotic Cutaneous Leishmaniasis
Mohammad Reza Shirzadi,
Amir Hamta,
Leyli Zanjirani Farahani,
Abedin Saghafipour,
Sadegh Rahi
Shirzadi MR, Hamta A, Zanjirani Farahani L, Saghafipour A, Rahi S. Comparative Assessment of Topical Glucantime® Injection Plus Cryotherapy and Cryotherapy Alone for Treatment of Anthroponotic Cutaneous Leishmaniasis. Arch Clin Infect Dis. 2021;16(3):e112222. doi: https://doi.org/10.5812/archcid.112222
30
Apr
2021
Effect of Adjunctive Topical Liposomal Azithromycin on Systemic Azithromycin on Old World Cutaneous Leishmaniasis: A Pilot Clinical Study
Bahareh Abtahi-Naeini,
Sajjad Hadian,
Fatemeh Sokhanvari,
Amirali Hariri,
Jaleh Varshosaz,
Zabihollah Shahmoradi
,et al.Abtahi-Naeini B, Hadian S, Sokhanvari F, Hariri A, Varshosaz J, et al. Effect of Adjunctive Topical Liposomal Azithromycin on Systemic Azithromycin on Old World Cutaneous Leishmaniasis: A Pilot Clinical Study. Iran J Pharm Res. 2021;20(2):e124526. doi: https://doi.org/10.22037/ijpr.2020.113710.14445
Cited by
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 11
Last Update: 3 weeks ago
- Scopus by Title (Ref): 11
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 7 hours ago
- OpenAlex: 0
Last Update: 1 day ago
- OpenCitations: 0
Last Update: 4 days ago
Comments
Number of Comments:0