Antibacterial activity of Zataria multiflora Boiss essential oil against extended spectrum ? lactamase produced by urinary isolates of Klebsiella pneumonia

Fereshteh Eftekhar; Samin Zamani; Morteza Yusefzadi; Javad Hadian; Samad Nejad Ebrahimi

Jundishapur Journal of Microbiology

Ahvaz Jundishapur University of Medical Sciences

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Antibacterial activity of Zataria multiflora Boiss essential oil against extended spectrum ? lactamase produced by urinary isolates of Klebsiella pneumonia

Author(s):

Fereshteh Eftekhar^1,*,

Samin Zamani²,

Morteza Yusefzadi³,

Javad Hadian²,

Samad Nejad Ebrahimi²

1Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, [email protected], Iran

2Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Iran

3Department of Marine Biology, Faculty of Sciences, Hormozgan

Jundishapur Journal of Microbiology:Vol. 4, issue Suppl; 43-49

Published online:Dec 31, 2011

Article type:Research Article

How to Cite:Eftekhar F, Zamani S, Yusefzadi M, Hadian J, Nejad Ebrahimi S. Antibacterial activity of Zataria multiflora Boiss essential oil against extended spectrum ? lactamase produced by urinary isolates of Klebsiella pneumonia. Jundishapur J Microbiol. 2011;4(Suppl):. doi:

Abstract

Introduction and objective: Klebsiella pneumoniae is an opportunistic pathogen most frequently associated with extended spectrum β-lactamase (ESBL) production. These organisms are usually resistant to most antibiotics and pose a serious threat for health care associated infections. Plant essential oils rich in carvacrol and thymol have gained importance for their antimicrobial activity. We determined the composition of Zataria multiflora essential oil of the Jandagh area in Iran and measured its activity against ESBL producing urinary isolates of K. pneumoniae.

Materials and methods: Essential oil was prepared from Z. multiflora at full flowering stage by hydrodistillation and its constituents were analyzed by a combination of capillary GC and GC-MS. Antibacterial activity was measured against 10 ESBL producing urinary isolates of K. pneumoniae as well as six ATCC bacterial standards by disc diffusion, minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) using broth microdilution.

Results: Zataria multiflora essential oil contained 25 constituents of which the major components were carvacrol (50.57%), thymol (13.38%) and p-cymene (8.27%). All tested bacteria were susceptible to the essential oil with the exception of Pseudomonas aeruginosa. Disc diffusion results showed inhibition zones of 18.3-30.3mm for the ATCC standards and 20.7- 29.7mm for the 10 clinical isolates. MIC and MBC values were 0.015- 2.0mg/ml for ATCC strains and 0.03 to 0.5mg/ml for the clinical isolates.

Conclusion: Zataria multiflora may have the potential to be used against multidrug resistant organisms such as clinical isolates of ESBL producing K. pneumoniae.

Keywords

Essential oil

Zataria multiflora

Antibacterial activity

Extended spectrum ?-lactamase (ESBL)

Klebsiella pneumonia

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Motevasel M, Okhovat MA, Zomorodian K, Farshad S. A Study of the Effect of Zataria multiflora Extract on Methicillin Resistant Staphylococcus aureus. Jundishapur J Microbiol. 2013;6(5):e5453. doi: https://doi.org/10.5812/jjm.5453

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Mojaddar Langroodi A, Ebadi Fathabad A, Moulodi F, Mashak Z, Alizade Khaled Abad M. Antioxidant and Antimicrobial Activities of Aqueous and Ethanolic Extracts of Barberry and Zataria multiflora Boiss Essential Oil Against Some Food-Borne Bacteria. J Kermanshah Univ Med Sci. 2018;22(2):e83087. doi: https://doi.org/10.5812/jkums.83087

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Author(s):

Fereshteh Eftekhar:[PubMed][Scholar]
Samin Zamani:[PubMed][Scholar]
Morteza Yusefzadi:[PubMed][Scholar]
Javad Hadian:[PubMed][Scholar]
Samad Nejad Ebrahimi:[PubMed][Scholar]

Ahvaz Jundishapur University of Medical Sciences

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Antibacterial activity of Zataria multiflora Boiss essential oil against extended spectrum ? lactamase produced by urinary isolates of Klebsiella pneumonia

Abstract

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