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Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
Authors
1Department of Pharmacology and Toxicology, School of Pharmacy, Physiology Research Center, Jundishapur University of Medical Sciences, IR Iran
2Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, b_ghorbanzadeh82@yahoo.com, IR Iran
*Corresponding Author: Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, b_ghorbanzadeh82@yahoo.com, IR Iran. Tel: +98-6113738380. Fax: +98-6113738381. Email: b_ghorbanzadeh82@yahoo.com
Published online:Feb 13, 2013
Article type:Research Article
Received:Jul 25, 2012
Accepted:Oct 20, 2012
How to Cite:Arzi A, Ghorbanzadeh B, Nazari Khorasgani Z. Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats. Jundishapur J Nat Pharm Prod. 2013;8(1):. doi: https://doi.org/10.17795/jjnpp-7404
Abstract
Objectives:
To investigate the antinociceptive activity of Iranian green tea extract.
Materials and Methods:
The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection.
Results:
The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1.
Conclusions:
These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways.
Highlights
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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