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Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
e-ISSN 2228-7876
p-ISSN 1735-7780
ANTIULCER ACTIVITY OF CRUDE ALCOHOLIC EXTRACTS OF BOUGAINVILLEA SPECTABILIS WILLD
Authors
11ROFEL Shri G.M Bilakhia College of Pharmacy, Vapi(West) -396 191, Valsad District, [email protected], Gujarat State, India
2Singapore 638 403
3Director, Asthagiri Herbal Research foundation, Tambaram Sanatorium, Chennai-600053 Tamilnadu, India
4India
*Corresponding Author: 1ROFEL Shri G.M Bilakhia College of Pharmacy, Vapi(West) -396 191, Valsad District, [email protected], Gujarat State, India. Email: [email protected]
Published online:Mar 30, 2007
Article type:Research Article
Received:Feb 14, 2006
Accepted:Apr 14, 2007
How to Cite:Malairajan P, Gopalakrishnan G, Narasimhan S, Jessi K. ANTIULCER ACTIVITY OF CRUDE ALCOHOLIC EXTRACTS OF BOUGAINVILLEA SPECTABILIS WILLD. Jundishapur J Nat Pharm Prod. 2007;2(1):. doi:
Abstract
The ethanol extract of Bougainvillea spectabilis (ALBS) leaves were studied for its antiulcer activity against aspirin plus pylorus ligation induced gastric ulcer, HCl /ethanol induced ulcer and water immersion stress induced ulcer in rats. The results were compared with ranitidine, sucralfate, omeprazole respectively, for each model suggesting a mechanism for the pharmacological action (antisecretory, cytoprotection, proton pump hypothesis were evaluated). The ethanol extract of Bougainvillea spectabilis showed reduction in gastric volume, free acidity, total acidity and the ulcer inhibition was found to be 100%. The plant extract showed significant cytoprotective effect 89.71% and the extract showed protection index 72% in water immersion stress induced ulcer.
Copyright
© 2007, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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