Fulltext
Fulltext is available in pdf file.
Jundishapur Journal of Natural Pharmaceutical Products
The Official Journal of Ahvaz Jundishapur University of Medical Sciences
Outlines
Method Validation for the One-Month Stability Study of trans–Resveratrol in Human Plasma
Author(s):
Milad Iranshahy1, 2, Amir Hooshang Mohammadpour3, Mohammad Hassanzadeh-Khayyat4, Mehrdad Iranshahi1, 2,*1Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran
2Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
3Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
4Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
*Corresponding Author: Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran. Tel: +98-5118823255, Fax: +98-5118823251, E-mail: [email protected] Email: [email protected]
Published online:May 04, 2013
Article type:Research Article
Received:May 20, 2019
Accepted:Jan 30, 2013
How to Cite:Iranshahy M, Mohammadpour AH, Hassanzadeh-Khayyat M, Iranshahi M. Method Validation for the One-Month Stability Study of trans–Resveratrol in Human Plasma. Jundishapur J Nat Pharm Prod. 2013;8(2):e94152. doi: https://doi.org/10.17795/jjnpp-9566
Abstract
Background: trans-Resveratrol (t-Res) is a natural phenolic compound with various biological activities such as antioxidant, anticancer, cancer chemopreventive, cardioprotective, and neuroprotective.
Objectives: There is no comprehensive study about the stability of t-Res in human plasma. With respect to extensive use of t-Res in clinical trials and pharmacokinetic studies, in this study, we aimed to measure the plasma stability of t-Res at different conditions of lighting, pH, and temperature, and in the presence of routine antioxidant agents (BHT and VIT C).
Materials and Methods: t-Res stability in human plasma was evaluated at different conditions of lighting, pH and temperature, and in the presence of routine antioxidant agents (BHT and VIT C), and quantitatively determined using HPLC-UV method at 306 nm.
Results: Our findings revealed that t-Res was quite stable in different temperatures ranging from -70 °C to 25 °C, and acidic pH conditions in plasma for a month, when protected from light, but it was unstable in alkali pH and in lighting conditions.
Conclusions: In lighting conditions, most of t-Res was isomerized to the other isomer cis-resveratrol. t-Res is unstable in alkali pH and when exposed to light. t-Res was quite stable at other conditions, and several freeze-thaw cycles did not have any effect on its stability.
Keywords
References
- 1.The references are available in PDF file.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
30
Apr
2019
The Impact of Resveratrol Supplementation on Inflammation Induced by Acute Exercise in Rats: Il6 Responses to Exercise
Reza Vafaee,
Hamidreza Hatamabadi,
Hamid Soori,
Mehdi Hedayati
Vafaee R, Hatamabadi H, Soori H, Hedayati M. The Impact of Resveratrol Supplementation on Inflammation Induced by Acute Exercise in Rats: Il6 Responses to Exercise. Iran J Pharm Res. 2019;18(2):e126240. doi: https://doi.org/10.22037/ijpr.2019.1100684
4
Aug
2017
Resveratrol: Is It Really Good for Liver Health?
Sabine Weiskirchen,
Ralf Weiskirchen
Weiskirchen S, Weiskirchen R. Resveratrol: Is It Really Good for Liver Health?. Hepat Mon. 2017;17(8):e12074. doi: https://doi.org/10.5812/hepatmon.12074
31
Oct
2013
Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities
Meherzia Mokni,
Sonia Hamlaoui,
Ines Karkouch,
Mohamed Amri,
Lamjed Marzouki,
Ferid Limam
,et al.Mokni M, Hamlaoui S, Karkouch I, Amri M, Marzouki L, et al. Resveratrol Provides Cardioprotection after Ischemia/reperfusion Injury via Modulation of Antioxidant Enzyme Activities. Iran J Pharm Res. 2013;12(4):e125752. doi: https://doi.org/10.22037/ijpr.2013.1404
30
Apr
2010
High-Performance Liquid Chromatographic Determination of Rivastigmine in Human Plasma for Application in Pharmacokinetic Studies
Hossein Amini,
Abolhassan Ahmadiani
Amini H, Ahmadiani A. High-Performance Liquid Chromatographic Determination of Rivastigmine in Human Plasma for Application in Pharmacokinetic Studies. Iran J Pharm Res. 2010;9(2):e126070. doi: https://doi.org/10.22037/ijpr.2010.845
3
May
2026
Effects of Resveratrol on Recovery from Acute Ischemic Stroke Among Patients Who Received Delayed Alteplase: A Double-Blind Placebo-Controlled Randomized Clinical Trial Study
Payam Sariaslani,
Hiwa Mohammadi,
Dalir Parsa,
Amirhosein Rostami Lal Abadi,
Shahab Rezaeian,
Shahla Mirzaei
Sariaslani P, Mohammadi H, Parsa D, Rostami Lal Abadi A, Rezaeian S, et al. Effects of Resveratrol on Recovery from Acute Ischemic Stroke Among Patients Who Received Delayed Alteplase: A Double-Blind Placebo-Controlled Randomized Clinical Trial Study. J Kermanshah Univ Med Sci. 2026;30(1):e170810. doi: https://doi.org/10.5812/jkums-170810
Download PDF671.37 KB
Crossmark
Checking
Comments
Number of Comments:0Cited by
- Scopus by DOI: 0
Last Update: 1 week ago
- Scopus by Title: 3
Last Update: 1 week ago
- Scopus by Title (Ref): 0
Last Update: 1 week ago
- CrossRef: 0
Last Update: 22 hours ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Search Relations
Author(s):
Related Articles