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Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review
1Department of Surgery, Lords Hospital, Anayara, Trivandrum, drvjady01@yahoo.co.in, India
2PGY-II, Family Medicine Residency, Howard University Hospital, USA
3Department of Medicine, Lords Hospital, Anayara, Trivandrum, India
*Corresponding Author: Department of Surgery, Lords Hospital, Anayara, Trivandrum, drvjady01@yahoo.co.in, India. Email: drvjady01@yahoo.co.in
Published online:Jan 31, 2010
Article type:Review Article
Received:Jul 31, 2009
Accepted:Aug 18, 2009
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of end stage renal disease and accounts for a substantial number of dialysis and transplant patients worldwide. Studies over the years have revealed precious information about the disorder's genetic profile, pathogenesis, systemic manifestations and its progression. An increased understanding of these aspects has enabled the development of clinical trials and potentially effective treatments.Relevant data on this topic was procured and synthesized with the aid of a comprehensive Medline search in addition to nephrologic and urologic literature review on ADPKD. The article provides an in-depth review into the natural history and pathogenesis of ADPKD; various clinical manifestations; progression of the disease; accuracy, reliability and need of screening and diagnostic procedures in different age groups; and novel therapeutic approaches that are being evaluated in ADPKD.
Highlights
How to Cite:Vijay1 A, Vijay A, Pankaj P. Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review. Nephro-Urol Mon. 2010;2(1):. doi:
Copyright
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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