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Nephro-Urology Monthly
Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective
Author(s):
1Department of Pharmacology and Medicine, The University of Toledo, Ohio, USA
*Corresponding Author: Department of Pharmacology and Medicine, The University of Toledo, Ohio, USA Email:
Published online:Apr 30, 2010
Article type:Review Article
Received:Sep 25, 2009
Accepted:Oct 17, 2009
How to Cite:Ratnam S, Nauli S. Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective. Nephro-Urol Mon. 2010;2(2):. doi:
Abstract
Cardiovascular complications are major causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). In particular, hypertension is insidious and remains a continuous problem that evolves during the course of the disease. Hypertension in ADPKD has been associated with abnormality in the renin-angiotensin-aldosterone system (RAAS). Early vascular changes have also been reported in young ADPKD patients. In addition, the cellular functions of mechanosensory cilia within vascular system have emerged recently. The basic and clinical perspectives of RAAS, vascular remodeling and sensory cilia are reviewed with regard to hypertension in ADPKD.
Copyright
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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