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Strategies to Extend Warm Ischemia Time During Laparoscopic Partial Nephrectomy-Part II
1Department of Urology, Saint Vincent Catholic Medical Centers, tdorai@svcmcny.org, USA
2Department of Urology, New York Medical College, New York, U.S
3Nephrology Section, Veterans Affairs Medical Center, U.S
*Corresponding Author: Department of Urology, Saint Vincent Catholic Medical Centers, tdorai@svcmcny.org, USA. Tel: +212-604-1556. Fax: +212-604-2073. Email: tdorai@svcmcny.org
Published online:Jan 31, 2010
Article type:Review Article
Received:Apr 25, 2009
Accepted:Jun 02, 2009
Abstract
In this part of the review, particular attention is drawn towards the mechanisms by which one can pre-condition the kidneys pre-operatively by using several strategies that are nutritional, biochemical, pharmacological and environmental in nature. In addition, ideas and hypotheses are put forward that are relevant to modulating the anoxic and autophagic response to ischemic damage during laparoscopic partial nephrectomy, particularly with respect to reducing the endoplasmic reticulum stress. Finally, the current trends in research involving the role of stem cells, renal hibernation and the role of the innate immune response are highlighted with the aim of exploiting these mechanisms to achieve reduced kidney damage during ischemia. Finally, the common thread behind all these approaches, namely empowering the renal mitochondria during ischemia is emphasized.
Highlights
How to Cite:Dorai T, Michels C, Goldfarb D, Grasso M. Strategies to Extend Warm Ischemia Time During Laparoscopic Partial Nephrectomy-Part II. Nephro-Urol Mon. 2010;2(1):. doi:
Copyright
© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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