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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Comparative Study of Intrathecal Dexamethasone with Epinephrine as Adjuvants to Lidocaine in Cesarean Section
Authors
Fereshteh Naziri1, S. Mozafar Rabiee1, Nadeia Banihashem1,*, Keyvan Hosseinjanzadeh1, Zeiba Shirkhani2, S. Sedigheh Solimanian2
1Department of Anaesthesiology and Intensive Care, Babol University of Medical Sciences, Babol, Iran
2Researcher, Babol University of Medical Sciences, Babol, Iran
*Corresponding Author: Department of Anaesthesiology and Intensive Care, Babol University of Medical Sciences, Babol, Iran Email: nbanihashem@yahoo.com
Published online:Jan 07, 2013
Article type:Research Article
Received:Jul 08, 2012
Accepted:Sep 20, 2012
How to Cite:Naziri F, Rabiee SM, Banihashem N, Hosseinjanzadeh K, Shirkhani Z, et al. Comparative Study of Intrathecal Dexamethasone with Epinephrine as Adjuvants to Lidocaine in Cesarean Section. Zahedan J Res Med Sci. 2013;15(9):e92848. doi:
Abstract
Background : Different additives have been used with local anesthetics to provide prolonged duration of sensory block in spinal anesthesia. The aim of present study was to evaluate the onset and duration of sensory block of intrathecal dexamethasone and epinephrine as adjuvants to lidocaine in patients who were candidate for cesarean section.
Materials and Methods : This double-blind clinical trial research was conducted on 90 pregnant women candidate for cesarean section under spinal anesthesia. Patients were randomly allocated to receive intrathecally either 75 mg hyperbaric lidocaine plus 100 μg epinephrine or 75 mg hyperbaric lidocaine plus 4 mg dexamethasone or 75 mg hyperbaric lidocaine. The onset and duration of sensory block as well as postoperative analgesia were assessed.
Results : The time to reach the peak sensory block in lidocaine group was shorter than that of other two groups (p<0.001). Duration of sensory block in the control group, dexamethasone group, and epinephrine group were 64.16±7.99 min, 74.79±12.78 min, and 99.30±10.93 min, respectively (p<0.001).
Conclusion : The present research shows that intrathecal dexamethasone and intrathecal epinephrine as adjuvant to lidocaine increases sensory block duration in the women candidate for cesarean section.
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References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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