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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
Outlines
Pathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat
Author(s):
Hossein Najafzadeh1,*, Hassan Morovvati2, Babak Mohammadian3, Mohammad Razijalali3, S.Mahsa Poormoosavi41Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
2Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
3Department of Pathology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
4Faculty of Veterinary Medicine, Shahid Chamran University,Ahvaz, Iran
*Corresponding Author: Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran Email: [email protected]
Published online:Dec 07, 2011
Article type:Research Article
Received:Aug 27, 2011
Accepted:Sep 29, 2011
How to Cite:Najafzadeh H, Morovvati H, Mohammadian B, Razijalali M, Poormoosavi S. Pathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat. Zahedan J Res Med Sci. 2012;14(7):e93314. doi:
Abstract
Background: Atorvastatin is a lipid-lowering drug used to treat hyperlipidemia. Phenobarbital is the inductor of cytochrome enzymes. This study examined the interfering effect of simultaneous consumption of these drugs on the biochemical and pathological changes in rat’s kidney.
Materials and Methods: Drugs were administered to 4 groups of Wistar rats (8 per group) for 15 days as follows: normal saline, atorvastatin, atorvastatin phenobarbital and phenobarbital alone. After anesthesia, blood was taken from the heart and serum was removed to measure myoglobin, creatinine, BUN, sodium, potassium and uric acid. After easy kill of rats, kidneys were removed and tissue sections were prepared through the conventional method of pathologic sections preparation and they were stained with Hematoxylin-Eosin, and pathological changes were examined by light microscopy.
Results: The simultaneous use of atorvastatin with phenobarbital significantly increased serum myoglobin of rats compared with control group. Pathological changes in the group receiving atorvastatin and phenobarbital simultaneously was observed with a greater intensity.
Conclusion: Phenobarbital can reduce renal toxicity of atorvastatin.
References
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Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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