Fulltext
The full text of this article is available on the PDF file.
Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Pathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat
Authors
Hossein Najafzadeh1,*, Hassan Morovvati2, Babak Mohammadian3, Mohammad Razijalali3, S.Mahsa Poormoosavi4
1Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
2Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
3Department of Pathology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
4Faculty of Veterinary Medicine, Shahid Chamran University,Ahvaz, Iran
*Corresponding Author: Department of Pharmacology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran Email: najafzadeh@scu.ac.ir
Published online:Dec 07, 2011
Article type:Research Article
Received:Aug 27, 2011
Accepted:Sep 29, 2011
How to Cite:Najafzadeh H, Morovvati H, Mohammadian B, Razijalali M, Poormoosavi S. Pathological Evaluation of Phenobarbital and Atorvastatin Co-Administration on Kidney of Rat. Zahedan J Res Med Sci. 2012;14(7):e93314. doi:
Abstract
Background: Atorvastatin is a lipid-lowering drug used to treat hyperlipidemia. Phenobarbital is the inductor of cytochrome enzymes. This study examined the interfering effect of simultaneous consumption of these drugs on the biochemical and pathological changes in rat’s kidney.
Materials and Methods: Drugs were administered to 4 groups of Wistar rats (8 per group) for 15 days as follows: normal saline, atorvastatin, atorvastatin phenobarbital and phenobarbital alone. After anesthesia, blood was taken from the heart and serum was removed to measure myoglobin, creatinine, BUN, sodium, potassium and uric acid. After easy kill of rats, kidneys were removed and tissue sections were prepared through the conventional method of pathologic sections preparation and they were stained with Hematoxylin-Eosin, and pathological changes were examined by light microscopy.
Results: The simultaneous use of atorvastatin with phenobarbital significantly increased serum myoglobin of rats compared with control group. Pathological changes in the group receiving atorvastatin and phenobarbital simultaneously was observed with a greater intensity.
Conclusion: Phenobarbital can reduce renal toxicity of atorvastatin.
Highlights
References
- 1.The References of this article are available on the PDF file.
Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
11
Aug
2025
Investigating the Effect of Atorvastatin on the Cisplatin-Induced Nephrotoxicity
Ali Rajaei,
Nasrin Namdari,
Alireza Rezvani,
Mehdi Dehghani
Rajaei A, Namdari N, Rezvani A, Dehghani M. Investigating the Effect of Atorvastatin on the Cisplatin-Induced Nephrotoxicity. Koomesh. 2025;27(4):e150141. doi: https://doi.org/10.69107/koomesh-150141
26
Aug
2020
Co-Administration of Morphine and Naloxone: Histopathological and Biochemical Changes in the Rat Liver
Tahmineh Peirouvi,
Yasaman Mirbaha,
Anahita Fathi-Azarbayjani,
Ali Shalizar Jalali
Peirouvi T, Mirbaha Y, Fathi-Azarbayjani A, Shalizar Jalali A. Co-Administration of Morphine and Naloxone: Histopathological and Biochemical Changes in the Rat Liver. Int J High Risk Behav Addict. 2020;9(3):e100594. doi: https://doi.org/10.5812/ijhrba.100594
31
Jan
2021
The Comparison of Antioxidant Effect of Aspirin, Metformin, Atorvastatin and Captopril Co-administration in the Heart and Kidney Tissues of Diabetic Rats
Maryam Paseban,
Saeed Niazmand
Paseban M, Niazmand S. The Comparison of Antioxidant Effect of Aspirin, Metformin, Atorvastatin and Captopril Co-administration in the Heart and Kidney Tissues of Diabetic Rats. Iran J Pharm Res. 2021;20(1):e124470. doi: https://doi.org/10.22037/ijpr.2019.112004.13481
28
Aug
2016
Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats
Sajedeh Mirshahvalad,
Farideh Feizi,
Aghdas Barkhordar,
Mohammad Bahadoram,
Gholamreza Houshmand,
Mahdi Pouramir
Mirshahvalad S, Feizi F, Barkhordar A, Bahadoram M, Houshmand G, et al. Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats. Jundishapur J Nat Pharm Prod. 2016;11(3):e33392. doi: https://doi.org/10.17795/jjnpp.33392
28
Sep
2016
Effects of different doses of manganese on lead poisoning in the kidney of adult male mice
Shabnam Mohammadi,
Mahbobeh Khakbaz,
Marzieh Shoraka,
Samira Vakil,
Maryam Moghimian,
Fatemeh mohammadzadeh
,et al.Mohammadi S, Khakbaz M, Shoraka M, Vakil S, Moghimian M, et al. Effects of different doses of manganese on lead poisoning in the kidney of adult male mice. koomesh. 2016;18(1):e151164. doi:
Cited by
- Scopus by DOI: 0
Last Update: 2 weeks ago
- Scopus by Title: 0
Last Update: 2 weeks ago
- Scopus by Title (Ref): 0
Last Update: 2 weeks ago
- CrossRef: 0
Last Update: 3 hours ago
- OpenAlex: 0
Last Update: 1 day ago
- OpenCitations: 0
Last Update: 4 days ago
Comments
Number of Comments:0