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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Association of Calcium-Sensing Receptor (CASR rs 1801725) with Colorectal Cancer
Authors
Akram Safaei1,*, Elaham Arbabi-Aval1, Maral Arkani1, Khatun Karimi1, Fatemeh Rostami1, Mohsen Vahedi1, Fateme Khorshidi1, Mitra Iman1, S. Reza Mohebi1, Mohamad Vafae2, S. Reza Fatemi1, Mohammad Reza Zali1
1Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Iranian Ostomy Society, Tehran, Iran
*Corresponding Author: Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Email: akramsafaei.134@gmail.com
Published online:Dec 25, 2011
Article type:Research Article
Received:Aug 20, 2011
Accepted:Oct 10, 2011
How to Cite:Safaei A, Arbabi-Aval E, Arkani M, Karimi K, Rostami F, et al. Association of Calcium-Sensing Receptor (CASR rs 1801725) with Colorectal Cancer. Zahedan J Res Med Sci. 2012;14(7):e93315. doi:
Abstract
Background: Calcium induces apoptosis in intestinal epithelial cells and subsequently prevents colorectal cancer through ion calcium receptor. Calcium-sensing receptor mutation reduces the expression of this receptor, and subsequently in reduces calcium transportation. Many studies have shown that Calcium-sensing receptor gene polymorphism may increase the risk of colorectal cancer. The purpose of this study is to assess the prevalence of calcium-sensing receptor polymorphisms (rs 1801725) in Iran society and to examine the role of this polymorphism in the increased risk of colorectal cancer (CRC).
Materials and Methods: The research was a case-control study. 105 patients with colorectal cancer and 105 controls were randomly studied using polymerase chain reaction and restriction fragment length polymorphism. χ2 test and software 16- SPSS were used for statistical analysis.
Results: In patient samples, the frequency of the genotypes TT, GT, GG in gene CASR rs 1801725 was respectively 64.8, 32.4, and 2.9 and the frequency of this polymorphism in control samples was respectively 51.2, 45.7, and 2.9. Frequency of allele G in patient samples was 0/48 and frequency of allele T was 0.25. In addition, Frequency of allele G in control samples was 0.74 and Frequency of allele T was calculated 0.19.
Conclusion: The results show that calcium-sensing receptor variant (1801725 rs) is not associated with increased risk of colorectal cancer.
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References
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Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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