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Zahedan Journal of Research in Medical Sciences
The Official Journal of Zahedan University of Medical Sciences
e-ISSN 2383-2894
Image Credit:Zahedan J Res Med Sci
Outline
Effect of Different Intensities of Short Term Aerobic Exercise on Expression of miR-124 in the Hippocampus of Adult Male Rats
Authors
1MSc of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.
2Associate professor of Exercise Physiology, School of Physical Education and Sport Science, University of Tehran, Tehran, Iran.
3Assistant professor of Hematology, Tarbiat Modares University, Tehran, Iran.
4MSc of Exercise Physiology, Sabzevar Islamic Azad University,Razavi Khorasan, Iran
*Corresponding Author: MSc of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran. Email: shmojtahedi@ut.ac.ir
Published online:Feb 29, 2012
Article type:Research Article
Received:Jan 26, 2012
Accepted:Feb 08, 2012
How to Cite:Mojtahedi S, Kordi M, Soleimani M, hosseini SE. Effect of Different Intensities of Short Term Aerobic Exercise on Expression of miR-124 in the Hippocampus of Adult Male Rats. Zahedan J Res Med Sci. 2012;14(2):e93575. doi:
Abstract
Background: One of the most specific miRNA of the brain is miR-124 which has been detected in the hippocampal area. This microRNA through suppression of some target genes, cause the stem cell to be changed into the neuron. The aim of this study was to identify the effect of exercise intensity on the expression of miR-124.
Materials and Method: Eighteenadult male Wistar rats were selected as subjects. The animals randomly divided into 3 groups of control (n=6) and runner (n=6). In low intensity group (n=6) animals daily, were allowed to run on treadmill with an intensity of about 35-40% of maximum oxygen consumption, daily for 30 minutes, of 2 weeks period. In high intensity group (n=6) the subjects were run in the same conditions but with an intensity of about 70-75% maximum oxygen consumption. After 24 hours of the last session of exercise, the animals were killed. Changes in expression analyzed using the quantitave RT-PCR technique.
Results: Statistical analysis by one-way ANOVA showed a statistically significant association between the intensities of exercise and elevated expression of miR-124 in the exercise group at significant level of p≤0.05.
Conclusion: To sum up, expression of miR-124, in the hippocampus of adult rats, is associated with exercise intensity and running forcefully in comparison with lower intensity, in which leads to robust changes in some mechanisms that involve in exercise- induced neurogenesis. [ZJRMS, 2012 14(2): 16-20]
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References
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Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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