Correlation between serum uric acid level in children with congenital heart disease and severe pulmonary hypertention

Background: This study evaluated correlation between serum uric acid level with pulmonary
hypertension and progress of pulmonary vascular disease in children with Congenital Heart
Disease (CHD) and Eisenmenger syndrome.
Methods: This case-control study was performed on 75 patients with congenital heart disease,
from Mar2001toApr2004that had referred to pediatric cardiology ward in Ali-Asghar hospital,
Zahedan and then cardiac catheterization performed at Khatam Hospital. Among 75 patients ,25
cases suffered from Eisenmenger syndrome (group 1), 25 cases had pulmonary hypertension
(group2) and25cases were in control with normal pulmonary artery pressure(group3).Then
collected data were analyzed with SPSS and Chi-square, Mann-Whitney, Kruskal-Wallis and
correlation tests and then results of three groups were compared to one another.
Results: Mean age in Eisenmenger syndrome (group1) was 2.75+/-2.23years,in pulmonary
hypertension (group2)3.52+/-3.76 and in control (group3)4.01+/-2.34 (P>0.05). There was no
significant statistical difference between three groups regarding age and sex.(P>0.05)The mean
pulmonary artery pressure was71.65+/-9.26 in group1,39.22+/-10.09 in group2 and 13.65+/-1.69
mmHg in group3.(P<0.001)The mean QP/QS ratio was 1.2+/-0.29 in group1,1.89+/-0.31 in
group2 and1+/-0 in group3.(P<0.001)The mean RV pressure was92.2+/-12.72mmHg in
group1,60.4+/-16.7 in group2 and25.44+/-3.29 in group3.(P<0.001)The mean pulmonary vascular
resistance was0.952+/-0.1 in group1,0.33+/-0.12 in group2,and0.13+/-0.01 in group3.(P<0.001)
there was a correlation between serum uric acid level and pulmonary vascular resistance in
group1.(r=0.425,P<0.034) The mean serum uric acid level was6.83+/-2.07mg/dl,4.01+/-
1.14,4.45+/-0.75 in the three groups respectively (P<0.05). Also this study showed that there is no
statistical significant relationship between mortality rate and serum uric acid in group1.
Conclusion: In this study, a significant correlation between increased serum uric acid level and
increased pulmonary vascular resistance in patients with Eisenmenger syndrome was found and
there was no a significant correlation between serum uric acid level and pulmonary vascular
resistance in other groups. So serum uric acid could be used for prediction of severity and progress
of Eisenmenger syndrome in children with congenital heart disease (CHD).