The comparison of titer of Helicobacter Pylori antibody in patients with gastric carcinoma and control group in Zahedan

Background: Gastric cancer is the second most common cause of cancer related death in the
world. Helicobacter pylori infection is associated with chronic gastritis, a known precursor of
gastric cancer. Carcinomas have been shown to be related to a high prevalence of H.Pylori
infection. We study titer of H.Pylori antibody in patients with gastric cancer and in patients with
non-ulcer dyspepsia.
Methods and Materials: During an eleven-month course (October 2001- September 2002) we
studied the relation between H. Pylori infection and gastric carcinoma in a case - control study in
Zahedan hospitals. The subjects divided into two groups; 40 control subjects and 40 patients with
gastric carcinoma. IgG Antibody to H. Pylori was checked in serum of patients in both groups by
ELISA method.
Results: Each group comprised of 21 male (52.5%) and 19 female (47.5%). Mean age was 53.18
and 56.58 years in control and case group, respectively. Anti-H. Pylori IgG was positive in 100% of
patients with gastric carcinoma but only in 28% of the control subjects. Chi-test demonstrated a
significant correlation between gastric cancer and Antibody test. (P= 0.000). Patients with gastric
carcinoma had higher titer of IgG 85.67 in contrast to those who did not have cancer.
Conclusions: Like other epidemiologic studies this study revealed that H. pylori infection is
associated with an increased risk of gastric carcinoma and is considered as a cofactor in the
pathogenesis of this malignant condition.