Background:Hemodynamic stability and blood loss reduction are subjects to further consideration in patients undergoing percutaneous nephrolithotomy (PNCL).
Objectives:This study compared the preference of spinal anaesthesia (SA) or general anaesthesia (GA) in respect to mentioned concerns.
Patients and Methods:In this randomized clinical trial, 59 patients who underwent PCNL divided into SA and GA groups. 15-20 mg from intra-thecal bupivacaine 0.5%, and premedication of 0.01-0.02 mg from midazolam, were given to patients in SA group (n = 29). Patients in GA group (n = 30) received premedication of 1-2 µg/kg from fentanyl and 0.01-0.02 mg/kg from midazolam, and intravenously anaesthetized with 100 µg/kg/min of propofol and 0.5 mg/kg of atracurium, given by continuous infusion and N2O/O2 50%. Mean arterial pressure (MAP) and heart rate were recorded intra-operatively and during recovery.
Results:MAP and heart rate show no significant differences at designated time points between two groups (P > 0.05). Surgery time, anesthesia time, bleeding volume, and analgesic intake were significantly reduced in SA group (P < 0.05).
Conclusions:It seems that, in patients undergoing PNCL, SA is as effective and safe as GA. Patients who undergo PNCL under SA require smaller amounts of analgesic dose and show hemodynamic stability during surgery and recovery time. Also, SA technique provides decreased blood loss and shortened surgery as well as anesthesia times compared to GA.
Nowadays, percutaneous nephrolithotomy (PNCL) is a common method for extracting renal and urinary stones, and a choice modality in large, multiple, and stag-horn stones. Furthermore, PNCL can be used in patients with failed shock and endoscopic trials (1-3). In about 20% of cases, urologic procedures are undertaken with general anesthesia (GA) or regional anesthesia such as spinal anesthesia (SA). Despite good results of PNCL with GA, it may cause atelectasis, drug reactions, nausea, and vomiting (4, 5). In abdominal and lower extremities surgeries, SA is mainly employed by a single drug and comprises some advantages such as less bleeding, and reduces venous pressure in the surgery field (6, 7). However, there are recent reports regarding the use of SA in PNCL demonstrating lower post-operation pain, less drug intake, and reduced adverse effects. Some studies have also shown that surgeries with SA had better outcomes in spinal surgeries (4, 5, 8).
There are controversies among researchers regarding the use of SA in PNCL due to the most important issue which is acute hypotension, resulting from sympathetic block (9-12). Therefore, BP and pulse rate (PR) can be helpful to monitor sympathetic drive in these patients. There are many studies comparing GA and SA in several surgeries (13-17); however, there is no definite comparison made by BP and PR in PNCL during surgery and in recovery room.
Considering the type of anesthesia as well as patients' hemodynamics that can influence on surgery outcomes and relevant morbidity and mortality of the intervention, and that these factors directly reflect on regional health-care, we aimed this study to compare mean BP and PR among PNCL patients underwent GA and SA.
3. Patients and Methods
In this randomized clinical trial, all patients referred to Shahid Hasheminejad hospital in 2011 as PNCL candidates were included sequentially if they met these inclusion criteria: age between 18-65 years with physical status I or II of American Society of Anesthesiologists (ASA). All patients with spinal deformity, local infection at injection site, pregnancy, history of any neuromuscular or psychiatric disorder or chronic pain, who were suffering from hypertension, diabetes and coagulation disorders, patients with hypersensitivity to any anesthesia drugs, substance abusers, and patients who needed anesthesia higher than T4 and lower than T10 levels were excluded. The included patients were divided into SA and GA groups using randomized number table. Standard monitoring included continuous electrocardiogram, pulse oximetry, and end-tidal carbon dioxide. Noninvasive BP measurements were performed at 5-min intervals. All patients were routed with a green (18-gauge) catheter and infused with 3-4 cc/kg isotonic crystalloids. Maintenance venous liquid during surgery was based on 4/2/1 rule. For blood loss limited to "maximum allowable blood loss", 3 mL of Ringer solution was injected for every 1 mL of blood loss, and equal volume of matched iso-group packed cell for more blood losses. Both types of anesthesia were performed by a 4th year resident of anesthesiology.
3.2. GA Group
Premedication of 1-2 µg/kg from fentanyl and 0.01-0.02 mg/kg from midazolam was administered. Oxygen with an inspired fraction of 1.0 was administered for 3 min before intubation. Then, GA was induced by 3-5 mg/kg thiopental-Na, and to obtain desired anesthesia, 0.5 mg/kg of atracurium was injected intravenously for easier intubation; then, all patients were intubated by a suitable endotracheal tube. For maintaining GA, an intravenous 100 µg/kg/min of propofol with 50% O2 and 50% N2O were induced. The ventilation protocol consisted of an inspired oxygen fraction of 1.0, inspiratory to expiratory ratio of 1:2, and a respiratory rate adjusted to normocapnia (end-tidal carbon dioxide partial pressure between 30 and 40 mmHg). Mechanical ventilation has been set with a tidal volume of 10 ml/kg ideal body weight (IBW) and ZEEP (zero-positive end expiratory pressure). Atracurium and fentanyl re-administration was based on train-of-four (TOF) and every 45 minutes, respectively.
3.3. SA Group
Premedication of 0.01-0.02 mg/kg from midazolam was administered. The patients were placed in a sitting position. The drug was administered by a 25-gauge Quincke needle in midline of L3-L4 or L4-L5 level by a physician. For inducing SA, isobar intra-thecal 15-20 mg of bupivacaine 0.5% without any additives was administered. Then, the patients' positions were changed to prone and intranasal 100% oxygen was administered. Sensory blockade was evaluated by a cotton peak (for heat perception) or a needle (for touching sense) every 15-20 seconds; then, motor blockade was tested by Bromage scale with following score: 0 = no paralysis; 1 = inability to raise extended leg; 2 = inability to flex knee; 3 = inability to move leg joints. Blood pressure below 100 mmHg of 30% from the baseline was corrected by 6 mg ephedrine and crystalloids, and all PR descents (less than 60/min) were treated by intravenous Atropine. All mentioned anesthetic drugs were provided by a regional pharmaceutical company (Darupakhsh, Iran).
3.4. Anesthesia Assessment
Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP), and PR were recorded every 20 minutes during surgery from the beginning of anesthesia. Intraoperative blood loss was calculated by blood volume of suction devices, and estimated volume of blood in sponges and drapes already were weighted before operation.
SBP, DBP, MAP, and PR were recorded in the PACU, every 10 min from entering PACU. Fifty mg from Meperidine was administered in patients suffered from additional pain. All patients were positioned in supine. MAP and PR were evaluated every 10 minutes for 1 hour. Other information were extracted from medical files and inserted into a pre-prepared checklist.
3.5. Ethical Issues
The patients were not charged by additional fees for the drugs used in any step of this study. The local ethics review committee of Iran University of medical sciences approved the study protocol. All participants gave written informed consent before participating.
3.6. Statistical Analysis
Based on a pilot study in 12 patients (six from each group), we determined that a sample size of 26 in each group would be sufficient to detect the differences between mean of blood loss and analgesic demand, estimate a standard deviation of 10, a power of 95%, and a significance level of 5%; this number was increased to 30 per group, to allow a predicted drop-out of around 10% from the study.
The data were evaluated and analyzed by SPSS version 19 (SPSS Inc., Illinois, USA). All quantitative data were expressed as mean ± SD, and qualitative data as No. (%). For comparing the groups, t-test and Mann-Whitney-U test were used for parametric and non-parametric data, evaluated by Kolmogorov-Smirnov test, respectively. P less than 0.05 were considered as significant.
4.1. Demographic Data
Fifty nine patients were enrolled in the study consisting of 38 males and 21 females. The patients were randomly divided into SA (n = 29) and GA (n = 30) groups. Table 1 demonstrates all demographic data. Surgery duration (P = 0.016) and anesthesia duration (P = 0.044) were significantly lower in SA (Table 2). According to Bromage scale, motor block level was zero in all patients in SA group.
|Variable||General Anesthesia||Spinal Anesthesia||P value|
|Surgery Duration, Mean ± SD, min||112.2 ± 18.3||99.3 ± 21.1||0.016|
|Anesthesia Duration, Mean ± SD, min||112.2 ± 18.3||101.3 ± 22.03||0.044|
|Recovery Duration, Mean ± SD, min||42.2 ± 12.8||41.5 ± 19.1||0.878|
|Blood Loss, Mean ± SD, ml||331.7 ± 151.1||211.03 ± 89.6||0.001|
|Analgesicdemand, Mean ± SD||6.3 ± 8.9||2.03 ± 6.3||0.038|
|Blood Transfusion, No. (%)||0.321|
|Positive||1 (3.3)||0 (0)|
|Negative||29 (96.7)||29 (100)|
4.2. Endpoint Results
In operation time-to-time analysis, SBP was significantly lower in GA group only in 120th minute; DBP in 60th, 90th, and 120th minutes, and MAP in 90th and 120th minutes (P < 0.05). The trend was not significantly different in none of 4 items (Figure 1; P > 0.05).
Table 2 demonstrates blood loss, analgesic demand, and blood transfusion amount in both groups. As seen, blood loss (P = 0.001) and analgesic demand (P = 0.038) were significantly higher in GA group.
Using SA in PNCL surgery is acceptable and more secure. By faster discharge and reduced recovery time, the patients’ quality of life can be improved using SA, which can be a good choice for urologist (18).
Overall, our study demonstrated that SBP, DBP, MAP, and PR in the whole surgery and recovery times did not have any significant difference between 2 groups, and that the trend was also somewhat similar in SA and GA; however, patients’ hemodynamics were more stable in SA group. Furthermore, bleeding and analgesic demand were significantly higher in GA group. None of the patients needed blood transfusion. These results were similar to other studies demonstrating that SA group had better hemodynamics and lower bleeding during and after the surgery (19-26).
In PACU, SBP was significantly lower in 10th, 20th, 30th, 40th minute; DBP and MAP in all evaluations and PR only in the 20th minutes were lower (P < 0.05). The trend was not significantly different in none of 4 items (Figure 2 ; P > 0.05).
It seems that SA can result in vasodilation and hypotension following sympathetic block. On the other hand, reduced intra-thoracic pressure and epidural vein distension, due to spontaneous ventilation, result in reduced bleeding. Therefore, the results do not seem to be irrational because SA can inhibit stress hormone secretion better than GA (27-30).
SA blocks preganglionic sympathetic nerves with many advantages compared to GA, such as redistribution of blood flow to musculoskeletal system, skin, and subcutaneous tissues, as well as reducing SBP, DBP, MAP, and PAP, and better hemostasis. Furthermore, other studies demonstrated better PNCL surgery results, lower blood loss, and lesser side effects (such as nausea, vomiting, and post-op pain) in SA (19, 31). Among these advantages of SA, decreasing blood loss is a main issue of SA in PCNL surgery. Recent studies investigated the effects of a 200-μg of oral clonidine tablet 60 - 90 minutes before anesthesia, which reduced blood loss significantly in several kinds of surgeries under GA that could be a future choice along with SA in PCNL (32, 33)
In McClain et al. study, SA could reduce the amount of anesthesia drugs, length of surgery time, and other side effects in discus decompression surgery (34). Tetzlaff et al. have also shown that in spinal surgeries, SA was a better choice for anesthesia compared to GA resulting in lower side effects (35). In an observational study, Mehrabi et al. evaluated 160 patients who underwent PCNL under spinal anesthesia in prone position. Blood transfusion was performed for ten patients (6.3%), and six patients complained of mild to moderate headache, dizziness, and mild postoperative low back pain for 2 to 4 days. Complete clearance of calculus or no significant residual calculi larger than 5 mm was achieved in 70% of patients (36). In another prospective randomized study on PCNL, 52 patients underwent general anesthesia and 58 patients received spinal anesthesia. PCNL was performed by standard technique. Intraoperative hypotension, postoperative headache, and low back pain were significantly higher in spinal group, but, compared to SA, the cost of anesthetic drugs was more than five times , and post-operative analgesic consumption about two times in GA group. Finally, authors suggested SA as a safe, effective, and cost-effective method in adult PCNL, the same as our results (37). Moreover , in other studies, additional analgesic consumption was reduced in SA group compared to GA group. This may be due to afferent nociceptive block of the spinal cord and faster block of sensory than that of motor nerves (13, 19).
In this study, patients with stone in upper pole of kidney, tolerated efficiently, but our sample size was designated for a whole kidney and not solely for upper pole; so because of general concerns about this subtype of kidney stones, future studies are needed with a study population designated for upper pole stones to compare competency and efficacy of SA versus GA.
In view of the results of our study, SA is a faster and safer method of anesthesia in PNCL surgeries. Using this method can help surgeons to maintain patient in a better hemodynamic and hemostatic state, reduce the GA complications, decrease the need of analgesics, and duration of surgery.
Stening SG, Bourne S. Supracostal percutaneous nephrolithotomy for upper pole caliceal calculi. J Endourol. 1998; 12 (4) : 359 -62 [PubMed]
Jun-Ou J, Lojanapiwat B. Supracostal access: does it affect tubeless percutaneous nephrolithotomy efficacy and safety? Int Braz J Urol. 2010; 36 (2) : 171 -6 [PubMed]
Kuzgunbay B, Turunc T, Akin S, Ergenoglu P, Aribogan A, Ozkardes H. Percutaneous nephrolithotomy under general versus combined spinal-epidural anesthesia. J Endourol. 2009; 23 (11) : 1835 -8 [DOI][PubMed]
Karacalar S, Bilen CY, Sarihasan B, Sarikaya S. Spinal-epidural anesthesia versus general anesthesia in the management of percutaneous nephrolithotripsy. J Endourol. 2009; 23 (10) : 1591 -7 [DOI][PubMed]
Wong MY. Evolving technique of percutaneous nephrolithotomy in a developing country: Singapore General Hospital experience. J Endourol. 1998; 12 (5) : 397 -401 [PubMed]
Singh V, Sinha RJ, Sankhwar SN, Malik A. A prospective randomized study comparing percutaneous nephrolithotomy under combined spinal-epidural anesthesia with percutaneous nephrolithotomy under general anesthesia. Urol Int. 2011; 87 (3) : 293 -8 [DOI][PubMed]
Urwin SC, Parker MJ, Griffiths R. General versus regional anaesthesia for hip fracture surgery: a meta-analysis of randomized trials. Br J Anaesth. 2000; 84 (4) : 450 -5 [PubMed]
Indelli PF, Grant SA, Nielsen K, Vail TP. Regional anesthesia in hip surgery. Clin Orthop Relat Res. 2005; 441 : 250 -5 [PubMed]
Sakura S. [Epidural anesthesia and spinal anesthesia in the elderly]. Masui. 2007; 56 (2) : 130 -8 [PubMed]
Ditzler JW, Dumke PR, Harrington JJ, Fox JD. Should spinal anesthesia be used in surgery for herniated intervertebral disk. Anesth Analg. 1959; 38 (2) : 118 -24 [PubMed]
Hassi N, Badaoui R, Cagny-Bellet A, Sifeddine S, Ossart M. [Spinal anesthesia for disk herniation and lumbar laminectomy. Apropos of 77 cases]. Cah Anesthesiol. 1995; 43 (1) : 21 -5 [PubMed]
Sadrolsadat SH, Mahdavi AR, Moharari RS, Khajavi MR, Khashayar P, Najafi A, et al. A prospective randomized trial comparing the technique of spinal and general anesthesia for lumbar disk surgery: a study of 100 cases. Surg Neurol. 2009; 71 (1) : 60 -5 [DOI][PubMed]
Hartmann B, Junger A, Klasen J, Benson M, Jost A, Banzhaf A, et al. The incidence and risk factors for hypotension after spinal anesthesia induction: an analysis with automated data collection. Anesth Analg. 2002; 94 (6) : 1521-9 [PubMed]
Kawase M, Komatsu T, Nishiwaki K, Kobayashi M, Kimura T, Shimada Y. Heart rate variability and arterial blood pressure variability show different characteristic changes during hemorrhage in isoflurane-anesthetized, mechanically ventilated dogs. Anesth Analg. 2002; 94 (1) : 16-21 [PubMed]
Covino BG. Rationale for spinal anesthesia. Int Anesthesiol Clin. 1989; 27 (1) : 8 -12 [PubMed]
Guedj P, Eldor J, Gozal Y. [Comparative study of conventional spinal anesthesia and combined spinal-epidural anesthesia in gynecological surgery]. Ann Fr Anesth Reanim. 1992; 11 (4) : 399 -404 [PubMed]
Niemi TT, Pitkanen M, Syrjala M, Rosenberg PH. Comparison of hypotensive epidural anaesthesia and spinal anaesthesia on blood loss and coagulation during and after total hip arthroplasty. Acta Anaesthesiol Scand. 2000; 44 (4) : 457 -64 [PubMed]
Seeberger MD, Lang ML, Drewe J, Schneider M, Hauser E, Hruby J. Comparison of spinal and epidural anesthesia for patients younger than 50 years of age. Anesth Analg. 1994; 78 (4) : 667 -73 [PubMed]
Stober HD, Mencke T. [General anesthesia or spinal anesthesia for hip prosthesis replacement? Studies of acceptance of both procedures by patients]. Anaesthesiol Reanim. 1999; 24 (6) : 151 -6 [PubMed]
Sutter PA, Gamulin Z, Forster A. Comparison of continuous spinal and continuous epidural anaesthesia for lower limb surgery in elderly patients. A retrospective study. Anaesthesia. 1989; 44 (1) : 47 -50 [PubMed]
Thorburn J, Louden JR, Vallance R. Spinal and general anaesthesia in total hip replacement: frequency of deep vein thrombosis. Br J Anaesth. 1980; 52 (11) : 1117 -21 [PubMed]
Davis FM, McDermott E, Hickton C, Wells E, Heaton DC, Laurenson VG, et al. Influence of spinal and general anaesthesia on haemostasis during total hip arthroplasty. Br J Anaesth. 1987; 59 (5) : 561 -71 [PubMed]
Cook PT, Davies MJ, Cronin KD, Moran P. A prospective randomised trial comparing spinal anaesthesia using hyperbaric cinchocaine with general anaesthesia for lower limb vascular surgery. Anaesth Intensive Care. 1986; 14 (4) : 373 -80 [PubMed]
Greenbarg PE, Brown MD, Pallares VS, Tompkins JS, Mann NH. Epidural anesthesia for lumbar spine surgery. J Spinal Disord. 1988; 1 (2) : 139 -43 [PubMed]
Kehlet H. The stress response to surgery: release mechanisms and the modifying effect of pain relief. Acta Chir Scand Suppl. 1989; 550 : 22 -8 [PubMed]
McLain RF, Kalfas I, Bell GR, Tetzlaff JE, Yoon HJ, Rana M. Comparison of spinal and general anesthesia in lumbar laminectomy surgery: a case-controlled analysis of 400 patients. J Neurosurg Spine. 2005; 2 (1) : 17 -22 [DOI][PubMed]
Ebneshahidi A, Mohseni M. Premedication with oral clonidine decreases intraoperative bleeding and provides hemodynamic stability in cesarean section. Anesth Pain. 2011; 1 (1) : 30 -3
Taghipour Anvari Z, Afshar-Fereydouniyan N, Imani F, Sakhaei M, Alijani B, Mohseni M. Effect of Clonidine Premedication on Blood Loss in Spine Surgery. Anesth Pain. 2011; 1 (4) : 252 -6
Tetzlaff JE, Dilger JA, Kodsy M, al-Bataineh J, Yoon HJ, Bell GR. Spinal anesthesia for elective lumbar spine surgery. J Clin Anesth. 1998; 10 (8) : 666 -9 [PubMed]
Mehrabi S, Karimzadeh Shirazi K. Results and complications of spinal anesthesia in percutaneous nephrolithotomy. Urol J. 2010; 7 (1) : 22 -5 [PubMed]
Mehrabi S, Mousavi Zadeh A, Akbartabar Toori M, Mehrabi F. General versus spinal anesthesia in percutaneous nephrolithotomy. Urol J. 2013; 10 (1) : 756 -61 [PubMed]