1. Background
Today in Iran, cancer is an important challenge to health care systems (1, 2). According to the annual report of the World Health Organization, the incidence of cancer was 12667470 new cases in 2008 and estimated to be over 15 million in 2020. Therefore, cancer pain may be a major problem for health care providers worldwide (3). According to different studies reporting the pain severity, one-third of patients reported to have moderate to severe pain (3). In patients with cancer pain, transdermal fentanyl patch could be an efficient and safe long-term analgesic method. There are four different forms of fentanyl transdermal patches 25, 50, 75 and 100 mcg/hour. The transdermal patch releases fentanyl at a constant rate for up to 72 hours. Fentanyl is a synthetic opioid with short-acting analgesic activity. The fentanyl patch is a proper option for cancer pain control. However, one of the most encountered problems is pain control deterioration because of decreased fentanyl release from the patch on the third day of treatment before patch replacement. It was reported that this complication would be seen in about one quarter of cases (3). The efficacy and onset of action of transdermal patches depend on many factors including the site of attachment, local and more generalized warmness and skin damage or abrasions. To minimize these conflicting effects, it has been suggested to: 1) patches should be applied to non-damaged skin of the deltoid muscle, lateral and dorsal thorax; 2) the area should be scraped and cleaned with water; and 3) no external heat application to the patch site (3). Fentanyl is a known opioid with unique property including a more potent opioid (∼ 75 times more than morphine), a smaller molecular mass, proper lipid solubility and greater transdermal permeability than morphine. These properties make it suitable for transdermal administration. Every fentanyl transdermal patch provides constant blood concentration of fentanyl for 72 hours. The blood concentration rises slowly and these properties reduce the risk of side effects. Fentanyl patch metabolites are not pharmacologically active and not affected by the first-pass effect in the liver or by gastrointestinal absorption. Furthermore, fentanyl has higher selectivity and affinity for μ1 receptors. Therefore, there is no side effect caused by μ2 receptors activation such as nausea, vomiting and constipation seen with morphine. In addition, there are no other side effects related to accumulation of metabolites.
Management of cancer pain is one of the most important goals of palliative care (4). Recently, different research results on the efficacy of opioid analgesics in chronic pain management played a role to implement standards in pain control worldwide (5). Pain is a highly prevalent and distressing symptom and a major health problem in patients with cancer (6). The pain incidence among patients with cancer ranges from 14-100% and occurs in 50-70% of patients in active phase of treatment. According to the literature reports, pain would be seen in as high as 60-90% of patients with advanced stages of cancer (7-9).
Most patients with cancer may require the use of opioid during the course of their illness. Cancer pain control can be achieved adequately in most patients with oral analgesics. However, in some instances, pain may not respond to optimal dosages of opioid. The main reason for this problem is the adverse effects before achieving a favorable analgesia or poor analgesic response despite rapid dosage escalation. Opioid drug change may be needed to identify the proper drug that yields the most suitable balance between analgesia and adverse effects. In some patients, side effects such as generalized nausea, vomiting, myoclonus, delirium or severe sedation may be developed before achieving adequate analgesia (10).
There have been many clinical trials on the efficacy and side effects of transdermal fentanyl patches for cancer and non-cancer pain control (11, 12). Compared with other opioids, fentanyl patches have been associated with better pain control, less side effects such as constipation, nausea, vomiting, myoclonus, delirium and somnolence. This drug promotes the quality of life (13, 14). The use of fentanyl patch, a potent opioid with continuous release of drug, provided new options and its benefit is evident for patients unable to take oral medications. Therapeutic safety of transdermal fentanyl varies widely among patients. Fentanyl serum concentrations increase gradually after initial application, and peak serum concentrations of fentanyl generally reached 12-48 hours after the initial application. As previously mentioned, we might encounter difficulties for adjusting the conversion (10).
The challenges of symptom associated with cancer pain make it difficult to implement high quality trials. Significant technical flaws have been recognized, including small trial size, lack of uniform scale of pain, as well as variability in the definition of statistically significant “pain relief”. In addition, there are no comparisons between opioids and other interventions, adjuvant medications, injections and blocks (6). In spite of increased knowledge of pain and its treatment in the recent years, treating pain of patients with cancer is often inadequate and results of fentanyl efficacy are controversial
2. Objectives
The aim of this study was to explore the effect of transdermal fentanyl patch in the treatment of chronic soft tissue cancer pain in a clinical trial of patients admitted to cancer institute, Imam Khomeini hospital, Tehran, Iran.
3. Patients and Methods
3.1. Study Design
The study design was a prospective descriptive study conducted from December 2006 to December 2007 at cancer institute, Imam Khomeini hospital, Tehran, Iran.
3.2. Setting
The study was confirmed by the research deputy of faculty of medicine, Tehran University of Medical Sciences. A written informed consent was obtained from patients.
3.3. Selection of Participants
Eighty-six patients with soft tissue tumors and chronic pain admitted to different wards of cancer institute, Imam Khomeini hospital, Tehran, Iran, were enrolled in the study. Inclusion criteria were age > 18, life expectancy > 3 months, assessable pain intensity and Visual Analogue Scale (VAS) > 3. The exclusion criteria were allergy to opioid, a history of opioid use, bilirubin ≥ 2 g/dL, creatinine level ≥ 2.0 mg/dL, active skin disease, critical respiratory disorders, asthma, fever above 40°C, impaired level of consciousness, Co2 retention, a history of radiotherapy, hormonal change and a history of chemotherapy in the last seven days. The study was approved by the University of Tehran Ethics Committee, and informed consent was obtained from all patients. All patients were fully informed about the procedure and the purpose of the experiment.
3.4. Intervention
Eighty-six patients with soft tissue cancer pain were included. Patients were unaware of the kind of drug administered. The pain severity was assessed before and after the treatment at different time intervals of 24, 48 and 72 hours. Standard VAS scale was used to evaluate the pain severity from zero to 10. No pain was considered as zero and the maximum pain ever experienced as 10. A general examination was performed by physicians after recording clinical and demographic characteristics. For all patients, transdermal fentanyl patch (25 μg/h) was administered. The patches were applied to flat areas of deltoid and replaced every 72 hours. We used a patch for 72 hours and only in five cases due to getting wet patch, a new patch was used. To evaluate the analgesic efficacy of patch, the degree of pain was assessed daily in the morning. The pattern of sleep was assessed daily using a qualitative five-point scale of “very well,” “well,” “normal,” “poor,” and “very poor.
3.5. Methods of Measurement
The safety and effectiveness of treatment was evaluated in the first day every eight hours and the next days once a day measuring blood pressure, pulse rate, respiratory rate and temperature. In the case of blood pressure decrease, bradycardia or loss of consciousness, we initiated supportive care and if the vital sign instability continued, patch was removed. Besides, the severity of side effects such as nausea, vomiting, sleepiness, constipation and skin changes was evaluated. Additional dosage of opioids or non-opioids and other drug treatment were documented.
3.6. Outcome Measures
Primary outcome was subsiding cancer pain in the first 12-18 hours after the initiation of treatment. The secondary objective was evaluating pain score in the next three days.
3.7. Primary Data Analysis
All statistical analyses were performed using SPSS version 13.0 (SPSS Inc., Chicago, IL). Categorical data were expressed as percentages and comparisons were made using χ2 tests. One-way ANOVA and independent t-test were used to compare parametric scores. P < 0.05 was considered as statistically significant. Values were presented as mean ± SD.
4. Results
Baseline patients' characteristics are shown in Table 1. None of 86 enrolled patients withdrew from the study. The VAS score before the treatment was not significantly different between the patients (P > 0.05).
| Variables | Fentanyl Group (n = 86) |
|---|---|
| Age, y | 45.5 ± 18 |
| Gender, male/female | 48/38 |
| Site of tumor | |
| Extremities | 38 (44.1) |
| Retroperitoneal | 26 (32.5) |
| Trunk and chest | 8 (9.3) |
| Head and neck | 12 (13.9) |
| Mediastinum | 2 (2.3) |
| Duration of pain, mo | 14.3 ± 20.2 |
Demographics and Baseline Characteristics of Patients a
4.1. Main Result
Patients who received transdermal fentanyl patch had a significantly lower pain in 24 hours,48 hours and 72 hours after the treatment (P = 0.001) (Table 2). The incidence of adverse events in transdermal fentanyl patch group was significantly high (72%). sleepiness in 26 (30.2%), Nausea and vomiting in 16 patients (18.6%) constipation in 16 patients (18.6%), pruritus in 2 patients (2.3%) and redness (Local redness ) in 2 patients (2.3%) were observed (Table 2).
| Outcome Parameters | Fentanyl (After) | P Value |
|---|---|---|
| VAS score before the treatment | 6.2 ± 0.7 | > 0.05 |
| VAS score after 24 hours of the treatment | 3.5 ± 0.8 | 0.001 |
| VAS score after 48 hours of the treatment | 3.4 ± 0.7 | 0.001 |
| VAS score after 72 hours of the treatment | 3.4 ± 0.7 | 0.001 |
| Number of side effect after the treatment | 24 (27.9) | - |
| Sleepiness | 26 (30.2) | 0.001 |
| Nausea and vomiting | 16 (18.6) | 0.001 |
| Constipation | 16 (18.6) | 0.001 |
| Redness | 2 (2.3) | 0.001 |
| Pruritus | 2 (2.3) | 0.001 |
Outcome Parameters (n = 86) a
5. Discussion
Fentanyl transdermal patch was approved by the FDA in 1990 and now used in more than 50 countries worldwide (15). This was the first clinical trial to evaluate the efficacy of transdermal fentanyl patch for the treatment of chronic soft tissue cancer pain in an Iranian population. Our result showed that the use of transdermal fentanyl patch significantly decreased the severity of pain in patients with cancer. This finding is consistent with some other studies (11-17). Fentanyl patch was reported to have fewer adverse events (2% to 30%) and the most frequently mentioned adverse events were nausea, vomiting and constipation (16-20). In other studies, adverse events were reported 72% in transdermal fentanyl patch (21). The most frequently mentioned adverse events were nausea, vomiting and sleepiness (22) and pain intensity remained stable and adverse events occurred in 20% of patients in 12-hour method (22). The studies support the effectiveness of fentanyl transdermal patch for treating cancer and non-cancer pain (23-28). In a systematic review of opioids consumption for cancer pain, fair evidence for the efficacy of transdermal fentanyl and poor evidence for morphine, tramadol, oxycodone, methadone and codeine were reported (29). There is a biopsychosocial experience with a significant cognitive and emotional component with cancer pain. Patients with anxiety and depression and cancer express higher levels of pain. There is a strong correlation between daily high-level distress and reporting high levels of pain (29).
However some recommendations are required for the safety of patients; cautious administration and close medical observations, in the first week daily contact by phone, and after that monthly visit in the outpatient setting (29). Sleepiness in transdermal fentanyl patch was one of the problems in patients. If it was possible to measure actual serum fentanyl level, the effective dosage with fewer adverse events was delivered. Further studies are needed to measure the actual serum fentanyl concentrations.
To conclude, fentanyl transdermal patch could provide stable pain control and removing the need for injections, thereby enhancing patient’s quality of life. Fentanyl transdermal patch (25 μg/hour) provided an effective treatment for cancer pain, but adverse events occurred in approximately 72% of patients. More educational programs on appropriate use of fentanyl transdermal patch for cancer pain management are required in Iran.
This study was conducted on a limited number of patients with soft tissue tumor. This was a limitation of the present study. This study could also be conducted on multiple cancer departments. Therefore, we recommend a new research with greater sample size in some sessions. Another limitation was not measuring the serum fentanyl concentration. Sleepiness was one of the adverse effects in patients. An effective dosage with fewer adverse events could be administered if serum fentanyl level was measured. Therefore, it is suggested to perform further studies to measure serum fentanyl concentrations.
