https://doi.org/10.5812/aapm.16316

Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-? in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass

authors:

avatar Parastou Aryana 1 , avatar Samira Rajaei 2 , avatar Abdolhamid Bagheri 3 , avatar Forouzan Karimi 4 , avatar Ali Dabbagh ORCID 1 , *

Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Immunology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Cardiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Immunology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Anesthesiology and Pain Medicine: Vol.4, issue 3; 16316
published online: June 16, 2014
article type: Research Article
received: November 20, 2013
accepted: December 24, 2013

how to cite: Aryana P, Rajaei S, Bagheri A, Karimi F, Dabbagh A. Acute Effect of Intravenous Administration of Magnesium Sulfate on Serum Levels of Interleukin-6 and Tumor Necrosis Factor-? in Patients Undergoing Elective Coronary Bypass Graft With Cardiopulmonary Bypass. Anesth Pain Med. 2014;4(3):16316. https://doi.org/10.5812/aapm.16316.

Abstract

Background:

Cardiovascular problems are among the most common health issues. A considerable number of cardiac patients undergo cardiac surgery, and coronary artery disease patients constitute about two-thirds of all these surgeries. The application of cardiopulmonary bypass (CBP) usually results in some untoward effects.

Objectives:

Studies have suggested magnesium sulfate (MgSO4) as an anti-inflammatory agent in a coronary artery bypass graft (CABG). This study aimed to assess the effect of an IV MgSO4 infusion during elective CABG (with CBP) on the blood levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-?).

Materials and Methods:

During a 12 month period, after review board approval and based on inclusion and exclusion criteria, 90 patients were selected and entered randomly into one of the two study groups (MgSO4 or placebo). Anesthesia, surgery and CBP were performed in exactly the same way, except for the use of MgSO4 or a placebo. Both preoperative and postoperative plasma levels of IL-6 and TNF-? were checked and compared between the two groups using an ELISA.

Results:

There was no difference found between the two groups with regard to; gender, basic variables, Ejection Fraction (EF), CBP time and aortic cross-clamp time. The preoperative levels of IL-6 and TNF-? were not different; however, their postoperative levels were significantly higher in the placebo group (P value = 0.01 for IL-6 and 0.005 for TNF-?).

Conclusions:

This study showed that MgSO4 infusion could suppress part of the inflammatory response after CABG with CBP. This was demonstrated by decreased levels of interleukin-6 and TNF-? in postoperative serum levels in elective CABG with CBP.

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