Anesthesiology and Pain Medicine
Mahzad Alimian1,*, Farnad Imani1, Valiollah Hassani1, Poupak Rahimzadeh1, Mahshid Sharifian1, Saeid Safari1Postoperative pain of dacryocystorhinostomy (DCA) surgery is one of the serious issues to be considered. Administrating opioids to relieve postoperative pain and facing their increasing side effects in eye surgeries, make the use of non-opioid drugs inevitable.
The present study examined the efficacy of pregabalin in alleviating the postoperative pain of DCA surgery.
The present study has been carried out as a double-blind, randomized clinical trial on the patient candidates for DCR. The patients were randomly divided in to two groups of pregabalin and placebo. Patients in pregabalin group received 300 mg of pregabalin, an hour before the operation in the morning of the surgery. Pain intensity on visual analog scale (VAS) was recorded until 24 hours after the operation; also the rate of administrated opioids and nausea/vomiting frequency were recorded during the first 24-hour period after the operation and the resultsof the two groups were compared.
Postoperative pain intensity in the pregabalin group at the time of recovery was significantly lower than that of the placebo group (P = 0.001) until 24 hours after the surgery. In the pregabalin group 17.5% of the patients received opioids while in the placebo group the figure was 52.5% (P = 0.001). Nausea frequency was also higher in the placebo group than the pregabalin group (P = 0.003).
A single 300 mg dose of pregabalin, an hour before DCA can effectively reduce pain intensity and also reduce opioid dose and nausea/vomiting.
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Borjian Boroojeny S, Faghihi H, Hojjat SM, Nasirodin Tabatabaei SM. Effects of Two Different Preoperative Doses of Pregabalin on Postoperative Pain After Lumbar Disc Herniation Surgery. Med Surg Nurs J. 2021;10(2):e120070. doi: https://doi.org/10.5812/msnj.120070
Rahimzadeh P, Imani F, Nikoubakht N, Koleini Z, Faiz SHR, et al. A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR). Anesth Pain Med. 2017;7(3):e45297. doi: https://doi.org/10.5812/aapm.45297
Ziyaeifard M, Mehrabanian MJ, Faritus SZ, Khazaei Koohpar M, Ferasatkish R, et al. Premedication With Oral Pregabalin for the Prevention of Acute Postsurgical Pain in Coronary Artery Bypass Surgery. Anesth Pain Med. 2015;5(1):e24837. doi: https://doi.org/10.5812/aapm.24837
Rao S, S PS, Ramakrishna R. Comparison of Two Preoperative Doses of Pregabalin for Attenuation of Postoperative Pain after Laparoscopic Cholecystectomy. J Cell Mol Anesth. 2021;6(2):e151396. doi: https://doi.org/10.22037/jcma.v6i3.33543
Alimian M, Imani F, Faiz SH, Pournajafian A, Navadegi SF, et al. Effect of Oral Pregabalin Premedication on Post-Operative Pain in Laparoscopic Gastric Bypass Surgery. Anesth Pain Med. 2012;2(1):. doi: https://doi.org/10.5812/aapm.4300
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