Abstract
Objectives:
The current study aimed at evaluating the effect of intraperitoneal infusion of normal saline (NS) and pulmonary recruitment maneuver (PRM) on the reduction of pain in shoulder, upper abdomen, and incision site after elective laparoscopic gynecologic surgery.Methods:
Totally, 280 patients (mean age: 30.5 years) that underwent laparoscopic gynecologic surgery from October 2013 to August 2015 were randomly and equally allocated into four groups. Group A received intraperitoneal infusion of NS 1.5 - 2 mL/kg of body weight; group B received PRM with five manual pulmonary inflations at a maximum pressure of 60 cm H2O; group C simultaneously received two former interventions; and finally the control group D received routine method of gentle abdominal pressure. All patients were assessed in the first 24 hours after surgery.Results:
There was an unsteady pattern for pain in shoulder, upper abdomen, and incision site at different time points across the studied groups over the trial. Patients in group B showed significantly lower shoulder pain 24 hours after laparoscopic gynecologic surgery (P = 0.01), while patients in group D had significantly lower incision site pain (P < 0.001).Conclusions:
PRM was superior to intraperitoneal infusion of NS for reducing pain in the first 24 hours after laparoscopic gynecologic surgery.Keywords
Pulmonary Recruitment Intraperitoneal Infusion Laparoscopy Pain Carbon Dioxide
1. Background
Laparoscopic surgery is getting more popular due to fast recovery. In addition, laparoscopic surgery needs smaller incision, has less postoperative pain, and lower rate of mortality in comparison with laparotomy (1, 2). The reports show that incidence of shoulder pain after laparoscopic gynecologic surgery is 80% (1). Shoulder pain can also be intense at 24 hours after laparoscopic hysterectomy (3).
Carbon dioxide (CO2) can be trapped in the space between liver and diaphragm after laparoscopic surgery. The trapped CO2 irritates phrenic nerve and causes pain in shoulder and upper abdomen (1). There are many ways to reduce postlaparoscopic shoulder pain including blowing low pressure gas, washing the diaphragm with local anesthetic, local anesthesia of peritoneal surface, and prescription of nonsteroidal anti-inflammatory drugs. However, these pain-reducing techniques have partial effects and there is no reliable method. Most of the available techniques are complicated and have limited clinical implications (4-6).
Recently, some techniques are introduced that can potentially alleviate various types of pain in patients after laparoscopic surgery. Intraperitoneal infusion of normal saline (NS), which washes out CO2 with physiologic buffer system, has long-time effect and may reduce pain in shoulder and upper abdomen after laparoscopic surgery (7, 8). The robust evidence indicates the potential beneficial effect of pulmonary recruitment maneuver (PRM) on reducing postoperative upper abdominal pain (9). The PRM may reduce pain by mechanically increasing intraperitoneal pressure to accelerate removing residual CO2 after operation (8, 10). However, the information about the potential beneficial effects of intraperitoneal infusion of NS and PRM is limited (1).
2. Objectives
The present randomized, controlled trial aimed at evaluating the effect of intraperitoneal infusion of NS and PRM on reducing pain in shoulder, upper abdomen, and incision site after laparoscopic gynecologic surgery.
3. Methods
3.1. Study Design
The current randomized, controlled, triple-blind trial was conducted on female patients undergoing gynecologic surgery from October 2013 to August 2015 in a referral hospital in Tehran, Iran. The study protocol was approved by the Ethics Committee of Tehran University of Medical Sciences (TUMS) and the study was also registered in the Iranian Registry of Clinical Trials (IRCT) prior to sample recruitment (IRCT201402022576N8).
3.2. Study Population
Patients aged 20 - 65 years with benign gynecologic diseases and ASA (American Society of Anesthesiologists) class I/II that underwent laparoscopic gynecologic procedures were included. Patients that underwent surgery for malignant indications were excluded. The subjects all signed an informed consent form before entering the study.
3.3. Interventions
Patients were randomly allocated to one of the four groups using a computer randomization program. The patients in the intervention groups received either (A) intraperitoneal infusion of NS, (B) PRM, or (C) simultaneously two former interventions. For group A, NS 1.5 - 2 mL/kg of body weight at 37°C was infused into left, middle, and right upper quadrants of abdomen at the end of the surgery. In group B, patients were placed in the Trendelenburg position and the anesthesiologist performed five manual pulmonary inflations at a maximum pressure of 60 cm H2O. PRM was performed mechanically using positive-pressure ventilation to inflate the lungs and lower diaphragm. Subjects in the control group (D) received the routine method by applying gentle abdominal pressure and residual CO2 was removed by passive deflation at the end of surgery.
3.4. Outcome Measures
Primary outcomes of the current study were pain in shoulder, incision site, upper abdomen, and adverse events such as nausea, vomiting, and distension. The outcomes were measured immediately after surgery as well as 2, 6, 12, and 24 hours after surgery. Visual analog scale (VAS) was used to evaluate pain intensity.
3.5. Statistical Analysis
Mean and standard deviation (SD) were calculated for the studied variables. The mean age and operation duration were compared among the intervention groups using the one-way analysis of variance (ANOVA). Multivariate repeated measures ANOVA adjusted for age was used to examine the effects of interventions and time on the outcome measures (i e, shoulder pain, upper abdominal pain, and incision site pain). Data were analyzed using SPSS version 19.0 (SPSS Inc., Chicago, IL, USA). The level of significance was P ≤ 0.05.
4. Results
A total of 280 patients with the mean age of 30.5 ± 7.7 years met the inclusion criteria. No statistically significant difference was observed in the mean duration of operation among the intervention groups (P ≤ 0.05) (Table 1). Multivariate repeated measures ANOVA showed unsteady pattern for pain in shoulder, upper abdomen, and incision site at different time points over the trial (Figures 1 - 3). Interaction of time interval and intervention status was statistically significant for shoulder and incision site pain (P ≤ 0.05). The study results showed potential beneficial effect of PRM on the reduction of postoperative shoulder pain; therefore, compared to other groups, patients receiving PRM had the medium level of shoulder pain 24 hours after surgery (mean = 0.4). The patients in the control group had the lowest incision site pain 24 hours after surgery (mean = 0.91) and the group received both interventions had lower incision site pain 24 hours after surgery (mean = 1.10) (Table 2). The occurrence of complications episodes across intervention groups during the first 24 hours after surgery was different; therefore, in the patients that simultaneously received both interventions, the total number of nausea and vomiting episodes was higher than the other groups; while the total number of occurrence of distension episodes in patients receiving intraperitoneal infusion of NS and routine methods were higher than those of the other groups (Figure 4).
Mean Duration of Operation Among the Intervention Groupsa
| Group | A (N = 70) | B (N = 70) | C (N = 70) | D (N = 70) | P Value |
|---|---|---|---|---|---|
| Duration of operation | 82.1 ± 8.1 | 78.8 ± 7.1 | 82.0 ± 9.7 | 77.7 ± 7.7 | 0.21 |
Changes from Baseline for the Studied Outcomes Measurea
| Variable | Follow-Up, min | P Valueb | ||||
|---|---|---|---|---|---|---|
| Recovery | 2 | 6 | 12 | 24 | ||
| Shoulder pain | 0.01 | |||||
| A | 0.22 ± 0.78 | 0.48 ± 1.22 | 0.43 ± 1.50 | 1.38 ± 1.49 | 1.05 ± 1.37 | |
| B | 0.14 ± 0.68 | 0.44 ± 1.27 | 0.77 ± 1.51 | 1.90 ± 2.41 | 0.40 ± 0.80 | |
| C | 0.20 ± 0.82 | 0.40 ± 0.92 | 1.04 ± 2.02 | 0.57 ± 1.17 | 0.80 ± 1.07 | |
| D | 0.79 ± 1.91 | 2.26 ± 2.65 | 0.89 ± 1.48 | 1.39 ± 1.49 | 1.24 ± 1.09 | |
| Upper abdominal pain | 0.16 | |||||
| A | 0.11 ± 0.53 | 0.26 ± 0.71 | 0.51 ± 0.92 | 0.28 ± 0.83 | 0.40 ± 0.82 | |
| B | 0.09 ± 0.44 | 0.10 ± 0.54 | 0.60 ± 1.22 | 0.71 ± 1.07 | 0.20 ± 0.73 | |
| C | 0.03 ± 0.23 | 0.16 ± 0.67 | 0.36 ± 0.94 | 0.60 ± 1.01 | 0.36 ± 0.72 | |
| D | 0.34 ± 1.35 | 0.23 ± 0.92 | 0.24 ± 0.69 | 0.51 ± 0.91 | 0.27 ± 0.70 | |
| Incision site pain | < 0.001 | |||||
| A | 0.75 ± 1.57 | 2.80 ± 2.65 | 2.49 ± 2.18 | 2.38 ± 2.00 | 1.34 ± 1.22 | |
| B | 2.44 ± 2.46 | 2.49 ± 2.17 | 2.44 ± 1.97 | 1.84 ± 1.92 | 1.21 ± 1.33 | |
| C | 0.77 ± 1.71 | 2.54 ± 2.63 | 2.71 ± 1.75 | 2.27 ± 1.51 | 1.10 ± 1.09 | |
| D | 2.47 ± 2.85 | 3.14 ± 2.75 | 2.07 ± 1.70 | 1.56 ± 1.46 | 0.91 ± 1.11 | |
Pain pattern in shoulder at different time points over the trial. A, normal saline intraperitoneal infusion; B, pulmonary recruitment maneuver; C, simultaneously received two interventions; D, control group.
Pain in upper abdomen at different time points over the trial. A, normal saline intraperitoneal infusion; B, pulmonary recruitment maneuver; C, simultaneously received two interventions; D, control group.
Pain in incision site at different time points over the trial. A, normal saline intraperitoneal infusion; B, pulmonary recruitment maneuver; C, simultaneously received two interventions; D, control group.
The total number of occurrence of complications episodes at different time points over the trial. A, normal saline intraperitoneal infusion; B, pulmonary recruitment maneuver; C, simultaneously received two interventions; D, control group.
5. Discussion
The results of the present randomized, controlled triple-blind trial showed that compared to the other interventions, PRM significantly decreased postoperative shoulder pain after 24 hours; while among the patients that received the routine method of gentle abdominal pressure, the incision site pain significantly decreased after 24 hours.
The potential beneficial effect of intraperitoneal infusion of NS is suggested to reduce pain after cholecystectomy (11, 12) and laparoscopic surgery for benign gynecologic lesions (8); but the current study, consistent with other studies (8-10), showed that PRM was superior to intraperitoneal infusion of NS in reducing postoperative pains. There was rare evidence about the effect of intraperitoneal infusion of NS and PRM on pain in incision site, but the current study findings showed that incision site pain was lower in patients receiving routine method of gentle abdominal pressure at 24 hours than the other groups.
The results of a study by Tsai et al., (8) comparing the effect of intraperitoneal infusion of NS with PRM in postoperative pain showed that compared to the control group, postoperative shoulder and upper abdominal pain decreased in patients receiving intraperitoneal infusion of NS or PRM. Although the evidence was consistent with the current study results, unlike the current study, they showed that intraperitoneal infusion of NS was more effective than PRM in reducing shoulder and upper abdominal pain after laparoscopic surgery for benign gynecologic lesions. The disagreement was probably due to difference in time of follow up; in the study by Tsai et al., the effect of intraperitoneal infusion of predominant NS was measured after 48 hours. Although intraperitoneal infusion of NS can be considered as a feasible technique, it is observed that due to abdominal fullness, the patients’ quality of life during the immediate postoperative period is decreased (9).
Treatment effect of applying intraperitoneal infusion of NS and PRM was assessed in a study (13); the study provided the evidence on potential beneficial effect of combined intervention of intraperitoneal infusion of NS and PRM to reduce postlaparoscopic shoulder and upper abdominal pain. In the current study, although employing the two interventions simultaneously could decrease shoulder pain compared to the control group, pain in upper abdomen was lower in the control group. It is argued that privileges of using the two interventions simultaneously are working with different mechanisms at different phases (13). It is documented that the effect of PRM diminished by 48 hours and PRM has short-time effects. On the contrary, intraperitoneal infusion of NS has long-time effects and its effect persists after 48 hours (8).
It is crucial to emphasize that the beneficiary effect of pain reducing techniques in elective laparoscopic gynecologic surgery in patients with ASA class ≥ III is still questionable. Future studies should also be conducted on the effect of these techniques in different patients. Recently, studies evaluating new methods and techniques to reduce postlaparoscopic shoulder pain are increasing; such as the new drug regimens including oral pregabalin (14), oral gabapentin (15), acetazolamide (16), and intraperitoneal sub-diaphragmatic instillation of bupivacaine plus morphine (17).
The current study had some strengths and limitations. The main strength of the present study was its efficient design; on the other hand, the sample size was statistically large enough to detect small differences between the two groups. The main limitation of the current study was short follow-up time; therefore, the effect of intraperitoneal infusion of NS appeared in 48 hours. In conclusion, the current study showed that PRM technique can be considered as a safe and easy technique to reduce pain in shoulder and upper abdomen after 24 hours in patients undergoing elective laparoscopic gynecologic surgery; in addition, patients receiving gentle abdominal pressure had lower incision site pain at 24 hours than other intervention groups.
Acknowledgements
References
-
1.
Kaloo P, Armstrong S, Kaloo C, Jordan V. Interventions to reduce shoulder pain following gynaecological laparoscopic procedures. Cochrane Database Syst Rev. 2019;1. CD011101. [PubMed ID: 30699235]. [PubMed Central ID: PMC6353625]. https://doi.org/10.1002/14651858.CD011101.pub2.
-
2.
Moslemi TF, Rasouli S. [Postoperative complications after ambulatory gyncologic laparaskopy: Comparison between three different techniques]. Med J Tabriz Univ Med Sci. 2010;31(12):69-75. Persian.
-
3.
Choi JB, Kang K, Song MK, Seok S, Kim YH, Kim JE. Pain characteristics after total laparoscopic hysterectomy. Int J Med Sci. 2016;13(8):562-8. [PubMed ID: 27499688]. [PubMed Central ID: PMC4974904]. https://doi.org/10.7150/ijms.15875.
-
4.
Dey A, Malik VK. Shoulder tip pain following laparoscopic cholecystectomy-a randomized control study to determine the cause. Indian J Surg. 2015;77(Suppl 2):381-4. [PubMed ID: 26730030]. [PubMed Central ID: PMC4692943]. https://doi.org/10.1007/s12262-013-0849-9.
-
5.
Haghgoo A, Chaichian S, Ghahremani M, Nooriardebili S, Akbaian A, Moazzami B. The use of peritoneal suction drainage to reduce shoulder pain caused by gynecological laparoscopy. Arch Iran Med. 2016;19(3):173-8. [PubMed ID: 26923888].
-
6.
Caesar Y, Sidlovskaja I, Lindqvist A, Gislason H, Hedenbro JL. Intraabdominal pressure and postoperative discomfort in laparoscopic Roux-en-Y Gastric Bypass (RYGB) surgery: A randomized study. Obes Surg. 2016;26(9):2168-72. [PubMed ID: 26861007]. https://doi.org/10.1007/s11695-016-2091-6.
-
7.
Esmat ME, Elsebae MM, Nasr MM, Elsebaie SB. Combined low pressure pneumoperitoneum and intraperitoneal infusion of normal saline for reducing shoulder tip pain following laparoscopic cholecystectomy. World J Surg. 2006;30(11):1969-73. [PubMed ID: 17043939]. https://doi.org/10.1007/s00268-005-0752-z.
-
8.
Tsai HW, Chen YJ, Ho CM, Hseu SS, Chao KC, Tsai SK, et al. Maneuvers to decrease laparoscopy-induced shoulder and upper abdominal pain: A randomized controlled study. Arch Surg. 2011;146(12):1360-6. [PubMed ID: 22184293]. https://doi.org/10.1001/archsurg.2011.597.
-
9.
Pergialiotis V, Vlachos DE, Kontzoglou K, Perrea D, Vlachos GD. Pulmonary recruitment maneuver to reduce pain after laparoscopy: A meta-analysis of randomized controlled trials. Surg Endosc. 2015;29(8):2101-8. [PubMed ID: 25361653]. https://doi.org/10.1007/s00464-014-3934-7.
-
10.
Sharami SH, Sharami MB, Abdollahzadeh M, Keyvan A. Randomised clinical trial of the influence of pulmonary recruitment manoeuvre on reducing shoulder pain after laparoscopy. J Obstet Gynaecol. 2010;30(5):505-10. [PubMed ID: 20604657]. https://doi.org/10.3109/01443611003802313.
-
11.
Huang M-L, Chao C, Mong F-Y, Tsao M-J. Intraperitoneal infusion of normal saline to reduce postoperative pain in patients receiving laparoscopic cholecystectomy: experience in MTYH. J Med Sci Taipei. 2001;21(6):273-6.
-
12.
Tsimoyiannis EC, Siakas P, Tassis A, Lekkas ET, Tzourou H, Kambili M. Intraperitoneal normal saline infusion for postoperative pain after laparoscopic cholecystectomy. World J Surg. 1998;22(8):824-8. [PubMed ID: 9673554].
-
13.
Tsai HW, Wang PH, Yen MS, Chao KC, Hsu TF, Chen YJ. Prevention of postlaparoscopic shoulder and upper abdominal pain: A randomized controlled trial. Obstet Gynecol. 2013;121(3):526-31. [PubMed ID: 23635614]. https://doi.org/10.1097/AOG.0b013e318283fcca.
-
14.
Nutthachote P, Sirayapiwat P, Wisawasukmongchol W, Charuluxananan S. A randomized, double-blind, placebo-controlled trial of oral pregabalin for relief of shoulder pain after laparoscopic gynecologic surgery. J Minim Invasive Gynecol. 2014;21(4):669-73. [PubMed ID: 24473153]. https://doi.org/10.1016/j.jmig.2014.01.018.
-
15.
Valadan M, Banifatemi S, Yousefshahi F. Preoperative gabapentin to prevent postoperative shoulder pain after laparoscopic ovarian cystectomy: A randomized clinical trial. Anesth Pain Med. 2015;5(6). e31524. [PubMed ID: 26705527]. [PubMed Central ID: PMC4688820]. https://doi.org/10.5812/aapm.31524.
-
16.
Rahimzadeh P, Faiz SHR, Hoseini M, Mousavie SH, Imani F, Negah AR. Comparison of intraperitoneal bupivacaine, acetazolamide, and placebo on pain relief after laparoscopic cholecystectomy surgery: A clinical trial. Med J Islam Repub Iran. 2018;32:112. [PubMed ID: 30815407]. [PubMed Central ID: PMC6387819]. https://doi.org/10.14196/mjiri.32.112.
-
17.
Sutchritpongsa P, Chaipakdi P, Sirimai K, Chalermchokcharoenkit A, Tanmahasamut P. Intraperitoneal sub-diaphragmatic instillation of bupivacaine plus morphine for reducing postoperative shoulder pain after gynecologic endoscopy. J Med Assoc Thai. 2013;96(5):513-8. [PubMed ID: 23745303].