Abstract
Background:
COVID-19 pandemic imposed significant challenges on the health systems. COVID-19 management policies such as lockdown have made access to the health centers difficult. Pregnant women are a high-risk group whose pregnancy outcomes may be affected by COVID-19 pandemic. So, it is necessary to determine changes in the prevalence of preterm births and complications of prematurity during the pandemic.Objectives:
This study aimed to determine the prevalence of preterm births and complications of prematurity during the first year of COVID-19 pandemic compared with the previous year.Methods:
In this cross-sectional study, we included all live births born between March 2019 to March 2021 in Mahdiyeh hospital, Tehran, Iran. We reviewed medical records to extract the prevalence of preterm births and prematurity complications. Then, the prevalence of preterm births and prematurity complications during COVID-19 pandemic compared with the previous year. We used Chi-square test to analyze categorical variables.Results:
A total of 10,830 live births were included in this study. During COVID-19 pandemic, the prevalence of moderate or late prematurity had a 4.64% reduction (P < 0.001), and the prevalence of term birth increased by 5.37% (P < 0.001) compared with the previous year. The prevalence of respiratory distress syndrome (RDS) decreased significantly during COVID-19 pandemic compared with the previous year (23.64% vs. 26.56%, P < 0.001). The prevalence of retinopathy of prematurity (ROP) significantly increased during COVID-19 pandemic compared with the previous year (3.97% vs. 2.28%, P < 0.001). Additionally, sepsis was significantly more prevalent during COVID-19 pandemic compared with the previous year (6.84% vs. 1.23%, P < 0.001). Moreover, intraventricular hemorrhage (IVH) significantly increased during COVID-19 pandemic in comparison to the previous year (1.10% vs. 0.08%, P < 0.001).Conclusions:
The prevalence of preterm birth decreased during COVID-19 lockdown. Also, major complications of prematurity such as RDS, ROP, sepsis, and IVH may be affected by COVID-19 lockdown.Keywords
1. Background
Coronavirus disease 2019 (COVID-19) was declared a pandemic in March 2020 by World Health Organization (WHO), soon after the first reports in China (1). Its dramatic rapid spread with considerable mortality and morbidity affected healthcare systems worldwide, even in fields not directly related to this infection (2). To minimize COVID-19 burden, many countries exerted nationwide lockdowns restricting access to medical centers for conditions other than COVID-19 (3-5).
Despite a significant improvement in the management of premature neonates, the complication of low birth weight and preterm labor are still noticeable (6). Besides, common multi-organ complications of prematurity, prolonged hospitalization, mechanical ventilation, broad-spectrum antibiotic therapies, and prenatal nutrition have several adverse effects. Therefore, it is reasonable to delineate factors affecting the pregnancy period to design more effective preventive guidelines for premature births (7-9). Recently, a study showed a significant reduction in premature births during COVID-19 lockdowns. Some probable factors were suggested to explain this reduction; however, the main reasons remained unclear (10).
2. Objectives
This study aimed to determine the prevalence of preterm births and complications of prematurity during the first year of COVID-19 pandemic compared with the previous year.
3. Methods
3.1. Study Design and Setting
This cross-sectional study was conducted at Mahdiyeh hospital, Tehran, Iran. We included all live births recorded in the Mahdiyeh hospital from March 2019 to March 2021. Live births were recorded from March 2020 to March 2021 that occurred during the first year of COVID-19 pandemic.
3.2. Data Collection
Data were collected by the census method. We reviewed medical records to extract the prevalence of preterm births and prematurity complications. Neonates were categorized regarding their gestational age (GA) (weeks + days) as follows: extremely premature (< 27w + 6d), very premature (28w, 31w + 6d), moderate or late premature (32w, 36w + 6d), term (37w, 41w + 6d), and late term (> 42w). Also, the following complications of prematurity were reviewed: Sepsis, intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and respiratory distress syndrome (RDS).
3.3. Data Analysis
Data were analyzed with SPSS (version 26). Descriptive data were reported as frequency and percentage. We used Chi-square test to compare variables between categories. Also, a P-value < 0.05 was considered statistically significant.
3.4. Ethical Considerations
This study was approved by the Institutional Research Ethics Committee Vice-Chancellor in Research Affairs of Shahid Beheshti University of Medical Sciences (approval ID: IR.SBMU.RETECH.REC.1399.1270). The study was a project based on the Helsinki Declaration 2000.
4. Results
A total of 10,830 live births were included in this study (5,232 were recorded after COVID-19 pandemic). Table 1 shows the prevalence of live births based on GA in detail. During COVID-19 pandemic, the prevalence of moderate or late prematurity had a 4.64% reduction compared with the previous year (P < 0.001). Besides, the prevalence of term labor during COVID-19 pandemic increased by 5.37% compared with the previous year (P < 0.001). In contrast, the prevalence of births among other GAs had no difference between the two periods. Overall, there was a significant association between the prevalence of births and gestational age (P < 0.001).
The Prevalence of Live Births Based on Gestational Ages
| Categories | Gestational Age; (Weeks + Days) | 2019 - 2020; No. (%) | 2020 - 2021; No. (%) | Risk Difference (%) a | P-Value b |
|---|---|---|---|---|---|
| Extremely premature | < 27 + 6 | 109 (1.95) | 81 (1.55) | -0.40 | 0.124 |
| Very premature | 28 - 31 + 6 | 146 (2.60) | 109 (2.08) | -0.52 | 0.072 |
| Moderate/ late premature | 32 - 36 + 6 | 948 (16.94) | 644 (12.30) | -4.64 | < 0.001 |
| Term | 37 - 41 + 6 | 4170 (74.5) | 4179 (79.87) | 5.37 | < 0.001 |
| Late term | > 42 | 225 (4.01) | 219 (4.20) | 0.19 | 0.676 |
| Total | - | 5598 (100) | 5232 (100) | - | - |
The prevalence of RDS decreased significantly during COVID-19 pandemic compared with the previous year (23.64% vs. 26.56%, P < 0.001). The prevalence of ROP significantly increased during COVID-19 pandemic compared with the previous year (3.97% vs. 2.28%, P < 0.001). Additionally, sepsis was significantly more prevalent during COVID-19 pandemic compared with the previous year (6.84% vs. 1.23%, P < 0.001). Moreover, IVH significantly increased during COVID-19 pandemic in comparison to the previous year (1.10% vs. 0.08%, P < 0.001). Figures 1 - 4 show the frequency of prematurity complications (RDS, ROP, sepsis, and IVH, respectively) based on gestational age. Also, Figure 5 shows time trend of preterm/term births and complications of prematurity.
The frequency of respiratory distress syndrome (RDS) based on gestational age
The frequency of retinopathy of prematurity (ROP) based on gestational age
The frequency of sepsis based on gestational age
The frequency of intraventricular hemorrhage (IVH) based on gestational age
A, Time trend of preterm/term births; B, Time trend of complications among preterm births; C, Time trend of complications among term births.
5. Discussion
Our study aimed to determine the prevalence of preterm births and complications of prematurity during the first year of COVID-19 pandemic compared with the previous year. Like the previous study (10), our results revealed that the prevalence of both preterm and term births altered during COVID-19 pandemic. Based on our results, late preterm pregnancies decreased obviously, in exchange for the increase in term births. We also assessed common complications of hospitalized neonates in both years. Our results noticed a considerable change in the above complications during the pandemic period. Although ROP and IVH increased during COVID-19 pandemic, they are unexplainable by the COVID-19 pathogenesis. These conditions are multifactorial and may be caused by hospitalization events. On the other hand, sepsis and RDS could be affected by prenatal care, which changed strongly during COVID-19 lockdowns.
This was the first study determining the prevalence of preterm births during COVID-19 pandemic in Iran. Since Mahdiyeh hospital is the major obstetrics and neonatal care center in the capital of Iran, Tehran, a large number of samples were available. Furthermore, no previous studies evaluated neonatal complications during national lockdowns. The duration of lockdown was short, and commitment to hygiene protocols was not satisfying for many months of the pandemic based on national surveys. These different situations in Iran led us to carry out this research.
Preliminary studies in European countries showed almost consistent outcomes with our findings. In the study by Been et al., the prevalence of preterm births was determined after lockdown implementation in the Netherlands. In this study, a significant reduction was observed in preterm births after mitigation measures. Besides, the prevalence of preterm births was not associated with socioeconomic status (6). A similar study in Denmark by Hedermann et al. revealed a substantially lower rate of extremely premature infants in contrast with the previous five years in which 3,1180 singleton births were assessed, and no considerable changes were observed among other GA groups (3). In another study by Philip et al. in Ireland, the rate of very low birth weight (VLBW) and preterm infants in the previous two decades were calculated. A significant reduction was revealed in preterm and VLBW neonates from January to April 2020. This study was conducted in a single health area, and preterm births were not categorized with GA (11). However, the impact of COVID-19 and lockdown on preterm births is controversial. Based on a meta-analysis by Vaccaro et al., conflicting results have been reported from 13 previous studies focusing on preterm births during COVID-19 lockdown. They stated an increase and a decrease in the incidence of preterm births, with odds ratios (95% confidence interval) between 0.09 (0.01 - 0.40) and 1.93 (0.76 - 4.79) (12).
Preterm labor is a multifactorial phenomenon (13). Both genetic and environmental factors can lead to this condition. To reduce this overwhelming problem, it is reasonable to decrease modifiable risk factors (14). It seems that focusing on self-hygiene, social distancing, less transportation, and less work stress may reduce the number of preterm births. However, the socioeconomic status may be altered drastically during lockdowns, leading to adverse health issues (15-17). COVID-19 pandemic affected healthcare systems dramatically worldwide. Caregivers and health facilities focused more on COVID-19 patients. As a result, access to health providers may be more difficult for conditions other than COVID-19, which may have consequences. Thus, further studies are needed to delineate the exact effect of COVID-19 management policies on preterm births.
Our study had some limitations. First, this was a single-center study, but a national survey with a further population may lead to different results. Second, due to the restriction of previous studies, the findings could not be completely interpreted and discussed. Third, we performed a cross-sectional study. Due to the study design, the impact of COVID-19 lockdown on the prevalence of preterm birth and prematurity complications could not be assessed. Thus, we suggest performing analytical studies in the future.
5.1. Conclusions
The prevalence of preterm birth decreased during COVID-19 lockdown. Also, major complications of prematurity such as RDS, ROP, sepsis, and IVH may be affected by COVID-19 lockdown.
References
-
1.
Zhang L, Dong L, Ming L, Wei M, Li J, Hu R, et al. Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection during late pregnancy: a report of 18 patients from Wuhan, China. BMC Pregnancy Childbirth. 2020;20(1):394. [PubMed ID: 32641013]. [PubMed Central ID: PMC7341473]. https://doi.org/10.1186/s12884-020-03026-3.
-
2.
Zheng T, Guo J, He W, Wang H, Yu H, Ye H. Coronavirus disease 2019 (COVID-19) in pregnancy: 2 case reports on maternal and neonatal outcomes in Yichang city, Hubei Province, China. Medicine (Baltimore). 2020;99(29). e21334. [PubMed ID: 32702930]. [PubMed Central ID: PMC7373607]. https://doi.org/10.1097/MD.0000000000021334.
-
3.
Hedermann G, Hedley PL, Baekvad-Hansen M, Hjalgrim H, Rostgaard K, Poorisrisak P, et al. Danish premature birth rates during the COVID-19 lockdown. Arch Dis Child Fetal Neonatal Ed. 2021;106(1):93-5. [PubMed ID: 32788391]. [PubMed Central ID: PMC7421710]. https://doi.org/10.1136/archdischild-2020-319990.
-
4.
Di Domenico L, Pullano G, Sabbatini CE, Boelle PY, Colizza V. Impact of lockdown on COVID-19 epidemic in Ile-de-France and possible exit strategies. BMC Med. 2020;18(1):240. [PubMed ID: 32727547]. [PubMed Central ID: PMC7391016]. https://doi.org/10.1186/s12916-020-01698-4.
-
5.
Lau H, Khosrawipour V, Kocbach P, Mikolajczyk A, Schubert J, Bania J, et al. The positive impact of lockdown in Wuhan on containing the COVID-19 outbreak in China. J Travel Med. 2020;27(3). [PubMed ID: 32181488]. [PubMed Central ID: PMC7184469]. https://doi.org/10.1093/jtm/taaa037.
-
6.
Been JV, Burgos Ochoa L, Bertens LCM, Schoenmakers S, Steegers EAP, Reiss IKM. Impact of COVID-19 mitigation measures on the incidence of preterm birth: a national quasi-experimental study. Lancet Public Health. 2020;5(11):e604-11. [PubMed ID: 33065022]. [PubMed Central ID: PMC7553867]. https://doi.org/10.1016/S2468-2667(20)30223-1.
-
7.
Leng Y, Huang W, Ren G, Cai C, Tan Q, Liang Y, et al. The treatment and risk factors of retinopathy of prematurity in neonatal intensive care units. BMC Ophthalmol. 2018;18(1):301. [PubMed ID: 30458733]. [PubMed Central ID: PMC6247707]. https://doi.org/10.1186/s12886-018-0973-1.
-
8.
Myrhaug HT, Brurberg KG, Hov L, Markestad T. Survival and Impairment of Extremely Premature Infants: A Meta-analysis. Pediatrics. 2019;143(2). [PubMed ID: 30705140]. https://doi.org/10.1542/peds.2018-0933.
-
9.
Jin YT, Duan Y, Deng XK, Lin J. Prevention of necrotizing enterocolitis in premature infants - an updated review. World J Clin Pediatr. 2019;8(2):23-32. [PubMed ID: 31065543]. [PubMed Central ID: PMC6477149]. https://doi.org/10.5409/wjcp.v8.i2.23.
-
10.
Green J, Petty J, Whiting L, Fowler C. Exploring modifiable risk-factors for premature birth in the context of COVID-19 mitigation measures: A discussion paper. J Neonatal Nurs. 2021;27(3):172-9. [PubMed ID: 33169065]. [PubMed Central ID: PMC7640921]. https://doi.org/10.1016/j.jnn.2020.11.004.
-
11.
Philip RK, Purtill H, Reidy E, Daly M, Imcha M, McGrath D, et al. Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: a 'natural experiment' allowing analysis of data from the prior two decades. BMJ Glob Health. 2020;5(9). [PubMed ID: 32999054]. [PubMed Central ID: PMC7528371]. https://doi.org/10.1136/bmjgh-2020-003075.
-
12.
Vaccaro C, Mahmoud F, Aboulatta L, Aloud B, Eltonsy S. The impact of COVID-19 first wave national lockdowns on perinatal outcomes: a rapid review and meta-analysis. BMC Pregnancy Childbirth. 2021;21(1):676. [PubMed ID: 34615505]. [PubMed Central ID: PMC8532086]. https://doi.org/10.1186/s12884-021-04156-y.
-
13.
Buen M, Amaral E, Souza RT, Passini RJ, Lajos GJ, Tedesco RP, et al. Maternal Work and Spontaneous Preterm Birth: A Multicenter Observational Study in Brazil. Sci Rep. 2020;10(1):9684. [PubMed ID: 32546709]. [PubMed Central ID: PMC7297738]. https://doi.org/10.1038/s41598-020-66231-2.
-
14.
Workalemahu T, Grantz KL, Grewal J, Zhang C, Louis GMB, Tekola-Ayele F. Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy. Sci Rep. 2018;8(1):7274. [PubMed ID: 29740100]. [PubMed Central ID: PMC5940684]. https://doi.org/10.1038/s41598-018-25706-z.
-
15.
Khalatbari-Soltani S, Cumming RC, Delpierre C, Kelly-Irving M. Importance of collecting data on socioeconomic determinants from the early stage of the COVID-19 outbreak onwards. J Epidemiol Community Health. 2020;74(8):620-3. [PubMed ID: 32385126]. [PubMed Central ID: PMC7298202]. https://doi.org/10.1136/jech-2020-214297.
-
16.
Chung RY, Dong D, Li MM. Socioeconomic gradient in health and the covid-19 outbreak. BMJ. 2020;369:m1329. [PubMed ID: 32238351]. https://doi.org/10.1136/bmj.m1329.
-
17.
Wu T. The socioeconomic and environmental drivers of the COVID-19 pandemic: A review. Ambio. 2021;50(4):822-33. [PubMed ID: 33507498]. [PubMed Central ID: PMC7841383]. https://doi.org/10.1007/s13280-020-01497-4.