https://doi.org/10.5812/archcid.19339

Spontaneous Bladder Rupture in a Patient With Human T-cell Lymphotropic Virus Type 1: A Case Report

authors:

avatar Masoud Mardani 1 , * , avatar Shabnam Tehrani 2 , avatar Marjan Hemmatian 2

Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Department of Infectious Diseases, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Archives of Clinical Infectious Diseases: Vol.9, issue 1; e19339
published online: January 25, 2014
article type: Case Report
received: December 14, 2013
accepted: December 18, 2013

how to cite: Mardani M, Tehrani S, Hemmatian M. Spontaneous Bladder Rupture in a Patient With Human T-cell Lymphotropic Virus Type 1: A Case Report. Arch Clin Infect Dis. 2014;9(1):e19339. https://doi.org/10.5812/archcid.19339.

Abstract

Introduction:

Spontaneous bladder rupture is a rare manifestation of hyporeflexic bladder due to HAM/TSP( human T-cell lymphotropic virus type 1 (HTLV1) associated myelopathy/tropical spastic paraparesis).

Case Presentation:

We report a case of spontaneous bladder rupture in a 62-year-old woman with a HTLV1 infection.

Discussion:

Bladder over-distention and spontaneous bladder rupture, although very rare in HAM/TSP, should be considered in a differential diagnosis of bladder rupture, especially in patients with a history of HTLV1.

1. Introduction

Spontaneous bladder rupture is a rare condition, with an incidence rate of 1/126000. In total, 70% of cases have been reported in men, and the overall mortality was 47% (1). It is usually the result of an underlying disease such as: blunt trauma to the lower abdomen, carcinoma of the pelvic organs, radiation therapy of pelvic tumors, large uretrovesical stones, catheterization of the bladder, atonic bladder, bladder irrigation, and neurogenic bladder dysfunction (2). One of the rare underlying diseases that can exhibit neurogenic bladder dysfunction is human T-cell lymphotropic virus type 1 (HTLV) (3).We present a case of spontaneous rupture of the urinary bladder in a patient with a history of HTLV1.

2. Case Presentation

A 62-year-old woman from the city of Mashhad (northeast of Iran) was admitted to Mehr Hospital, Tehran; with a chief complain of sudden onset generalized abdominal pain from four hours ago. The pain was continuous in nature, diffusely involved the whole abdomen, and the pain was non-radiating, no other lower urinary tract orgastrointestinal (GI) symptoms were present. In her past medical history, there was a history of HTLV1 from one year ago (positive HTLV1 antibodies Elisa and Western blot). She also complained of gradually progressive voiding problems, such as: frequency, dysuria, nocturia, and urge incontinence, for a period of six months. Treatment with conventional interferon α three times a week was started based upon a diagnosis of overactive bladder syndrome due to HAM/TSP. However, one month ago the sensation of incomplete voiding and hesitancy became worse, regretfully this situation was not followed up by the patient. No other risk factors such as: trauma, malignancy, or radiation were found in her past medical history.

On physical examination: she was alert, ill, and pale. Vital signs: blood pressure (BP) = 80/60 mmHg, pulse rate (PR) = 150/minute, respiratory rate (RR) = 24/minute, temperature (T) = 38, an abdominal examination revealed a distended abdomen, bowel sounds were absent, and diffuse tenderness over the whole abdomen with positive rebound tenderness. Laboratory tests were as hemoglobin= 9 mg/dL, white blood cell= 18000/mm3 (net: 78% L: 16%), platelet count =138000/mm3, creatinine level = 1. 9 mg/dL, blood urea = 36 mg/dL, LDH = 498 U/L, AST = 83 U/L, Alt = 33 U/L, total bilirubin = 0/6 (direct = 0/4), negative hepatitis B surface (HBS) Ag, anti HCV Ab, anti-human immunodeficiency virus (HIV) Ab.

An x-ray of the abdomen showed gas under the diaphragm and an abdominal ultrasound revealed free fluid in the abdomen. Based on the clinical and radiological findings the patient underwent a laparotomy, which showed a rupture of the urinary bladder fundus. A bladder biopsy showed necrotizing inflammation and gangrene, but negative for granuloma and malignancy. According to her past medical history of HTLV1, detrusor hypo-sensitivity, hypo-activity and bladder rupture due to bladder over-distension associated with HAM/TSP, were diagnosed. During a laparotomy, the site of the perforation was repaired and the patient is now undergoing treatment for HTLV1, as a result she has remained asymptomatic after her surgery till the present time.

3. Discussion

HTLV1 is a complex retrovirus belonging to the delta virus family (4). HTLV1 infects 10 to 20 million people worldwide: Southern Japan, the Caribbean, Central and South Africa, South America, and the northeast of Iran are the endemic foci (5). The prevalence of HTLV1 infections in Mashhad City (northeast of Iran) is 1.16% (6, 7), and HTLV1 infects the body’s CD4 cells. There are several routes of viral transmission, including: sexual, mother to baby, transfusion, needle stick, and breast feeding (8). The standard practice for a diagnosis of HTLV1 infection is the detection of antibodies by an enzyme immunoassay (EIA) technique, followed by a confirmatory test with Western blot or molecular methods (9). HTLV1 has two major clinical presentations: 1) adult T-cell leukemia lymphoma (ATLL) and 2) a neurologic disease called HAM/TSP (10). Patients with HAM/TSP present with spastic paraparesis in the lower extremities, mild disturbance of sensation and urinary dysfunction (8). The pathogenesis of neurological manifestationsin a HTLV1 infection arepoorly understood. Up to 90% of HAM/TSP patients have urologic manifestations, such as: urgency, nocturia, urge incontinence, dysuria, and straining (11, 12). In the aforementioned group, the major abnormality is over-active bladder syndrome, and detrusor over-activity, followed by detrusor external sphincter dyssynergia (13). However, 3.84% of patients showed a hyporeflexic bladder and detrusor hypo-sensitivity and hypo-activity. In this group, the urological manifestation is bladder over-distention, secondary to a large volume of urine, which in turn causes hesitancy, sensation of incomplete voiding, and spontaneous bladder rupture (14). A diagnosis of bladder rupture is difficult to make and it requires a high index of suspicion. The most common presentation is diffuse abdominal pain and lower abdominal tenderness, confirmation of the diagnosis is almost always done with a laparotomy (5). In conclusion, bladder over-distention and spontaneous bladder rupture, although very rare in HAM/TSP patients, should be kept in mind when making a differential diagnosis of spontaneous bladder rupture, especially in a high HTLV1 prevalence country such as ours. In addition, aurodynamic evaluation should be performed in all HTLV1 infected individuals with voiding complaints.

References

  • 1.

    Basavaraj DR, Zachariah KK, Feggetter JG. Acute abdomen--remember spontaneous perforation of the urinary bladder. J R Coll Surg Edinb. 2001;46(5):316-7. [PubMed ID: 11697704].

  • 2.

    Saleem MA, Mahmoud AM, Gopinath BR. Spontaneous urinary bladder rupture: a rare differential for lower abdominal pain in a female patient. Singapore Med J. 2009;50(12):e410-1. [PubMed ID: 20087542].

  • 3.

    Heyns CF, Rimington PD. Recurrent spontaneous bladder rupture. A case report. S Afr Med J. 1989;75(9):445-6. [PubMed ID: 2718073].

  • 4.

    Santos SB, Oliveira P, Luna T, Souza A, Nascimento M, Siqueira I, et al. Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection. J Med Virol. 2012;84(11):1809-17. https://doi.org/10.1002/jmv.23341.

  • 5.

    Feizzadeh K. B, Boostani R, Ghoreifi A. Recurrent Spontaneous Rupture of the Urinary Bladder in a Patient With Human T-lymphotropic Virus Type 1-Associated Myelopathy: A Case Report and Literature Review. Nephrourol Mon. 2014;6(2). https://doi.org/10.5812/numonthly.11764.

  • 6.

    Nemati Karimooy H, Hassanabady H, Rafatpanah H. Four cases of polyneuropathy due to HTLV-1 infection in Imam Reza Hospital: North East of Iran. Pak J Med Sci. 2007;23(2):283.

  • 7.

    Tavanai SA. Serologic prevalence of HTLV1 among blood donors in Mashhad (Northeastern Iran). Arch In med. 2001;41:25-6.

  • 8.

    Jonelle M, Pets cavage MD, Hazel Mulcahy MD, Richardson MD. HTLV1 associated myelopathy. Radiology case reports. 2011. https://doi.org/10.2484/rcr.v612.416.

  • 9.

    Canelo-Aybar C, Cuadra-Urteaga J, Atencia F, Romani F. Human T Lymphotropic virus-1 associated gastrointestinal histoplasmosis in Peru. J Infect Dev Ctries. 2011;5(6):484-8. [PubMed ID: 21727649].

  • 10.

    Albertino F, Botto Micca F, Gasparri G, Casalegno PA, Oliaro A, Dei Poli M. [Multifocal early cancer of the esophagus]. Minerva Chir. 1987;42(10):839-42. [PubMed ID: 3627489].

  • 11.

    Araujo AQC, Leite ACC, Lima MASD, Silva MTT. HTLV1 and neurological Conditions: when to suspect and when to order a diagnosis test for HTLV1 infection? Arg Neuropsiquiatr. 2009;67:132-8. https://doi.org/10.1590/50004.

  • 12.

    Castro NM, Freitas DM, Rodrigues W, Jr, Muniz A, Oliveira P, Carvalho EM. Urodynamic features of the voiding dysfunction in HTLV-1 infected individuals. Int Braz J Urol. 2007;33(2):238-44. [PubMed ID: 17488545].

  • 13.

    Oliveira P, Castro NM, Carvalho EM. Urinary and sexual manifestations of patients infected by HTLV-I. Clinics. 2007;62(2):191-6.

  • 14.

    Lima CL, Rabolini G, Menna-Barreto M, Dos Santos EB, Koff WJ. Urodynamic alterations in patients with HTLV-1 infection. Int Braz J Urol. 2002;28(5):452-6. [PubMed ID: 15748372].