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Evaluation of Diabetes Mellitus in Patients with Sepsis

Author(s):
Mitra BaratiMitra Barati1,*, Mahshid Talebi TaherMahshid Talebi Taher1, Fatemeh GolgiriFatemeh Golgiri2
1Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, IR Iran
2Department of Endocrinology, Iran University of Medical Sciences, Tehran, IR Iran


Archives of Clinical Infectious Diseases:Vol. 3, issue 4; 221-5
Article type:Brief Report
How to Cite:Mitra BaratiMahshid Talebi TaherFatemeh GolgiriEvaluation of Diabetes Mellitus in Patients with Sepsis.Arch Clin Infect Dis.3(4):221-5.

Abstract

Background:

Diabetes mellitus is a prevalent disease worldwide and infection is a major problem in diabetics. This study investigated the frequency of diabetes mellitus and its associated factors in patients with sepsis.

Patients and methods:

This is a descriptive cross-sectional study including 300 randomly selected cases admitted to Rasoul-e-Akram Hospital with the diagnosis of sepsis between March 2003 and February 2006.

Results:

Of 300 septic patients, 158 (52.7%) had diabetes mellitus with the mean age ( standard deviation) of 52.728.4 years. The most common site of infection was respiratory tract. Evaluation of the outcome of patients in two diabetic and non-diabetic groups demonstrated a statistical difference (p=0.001). Mortality rate increased with aging, delay in therapy commencement and the number of SIRS criteria (p=0.001). Evaluation of the mortality rate in 3 diabetic groups (blood glucose> 250, 180-250 and <180 mg/dl) demonstrated a statistical difference (P= 0.001).

Conclusion:

Aging can increase the rate of sepsis and its associated mortality in both diabetic and non-diabetic patients. Mortality of sepsis is more in diabetics when compared with non-diabetics. Severity of disease (further SIRS criteria) increases mortality and tight control of blood glucose may be associated with better prognosis.

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