article information

Archives of Clinical Infectious Diseases: Vol.3, issue 4; 221-5
article type: Brief Report

Evaluation of Diabetes Mellitus in Patients with Sepsis

authors:

avatar Mitra Barati 1 , * , avatar Mahshid Talebi Taher 1 , avatar Fatemeh Golgiri 2

Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, IR Iran
Department of Endocrinology, Iran University of Medical Sciences, Tehran, IR Iran

how to cite: Barati M, Talebi Taher M, Golgiri F. Evaluation of Diabetes Mellitus in Patients with Sepsis. Arch Clin Infect Dis. 2008;3(4): 221-5. 

Abstract

Background:

Diabetes mellitus is a prevalent disease worldwide and infection is a major problem in diabetics. This study investigated the frequency of diabetes mellitus and its associated factors in patients with sepsis.

Patients and methods:

This is a descriptive cross-sectional study including 300 randomly selected cases admitted to Rasoul-e-Akram Hospital with the diagnosis of sepsis between March 2003 and February 2006.

Results:

Of 300 septic patients, 158 (52.7%) had diabetes mellitus with the mean age ( standard deviation) of 52.728.4 years. The most common site of infection was respiratory tract. Evaluation of the outcome of patients in two diabetic and non-diabetic groups demonstrated a statistical difference (p=0.001). Mortality rate increased with aging, delay in therapy commencement and the number of SIRS criteria (p=0.001). Evaluation of the mortality rate in 3 diabetic groups (blood glucose> 250, 180-250 and <180 mg/dl) demonstrated a statistical difference (P= 0.001).

Conclusion:

Aging can increase the rate of sepsis and its associated mortality in both diabetic and non-diabetic patients. Mortality of sepsis is more in diabetics when compared with non-diabetics. Severity of disease (further SIRS criteria) increases mortality and tight control of blood glucose may be associated with better prognosis.

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