Rabies Neutralizing Antibody Level in Immunosuppressed Patients After Receive of Rabies Post-Exposure Prophylaxis

Vida Fallahian; Ali Eslamifar; Mohammad Amin Fayaz; Parisa Mashayekhi; Peyvand Biglari

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Rabies Neutralizing Antibody Level in Immunosuppressed Patients After Receive of Rabies Post-Exposure Prophylaxis

Author(s):

Vida Fallahian^,*,

Ali Eslamifar³,

Mohammad Amin Fayaz⁴,

Parisa Mashayekhi²,

Peyvand Biglari¹

3Department of Clinical Research, Pasteur Institute of Iran, Tehran, IR Iran

4Student of Veterinary Faculty of Tehran University, Tehran, IR Iran

2Prevention and Treatment of Rabies Center, Department of Vaccination, Pasteur Institute of Iran, Tehran, IR Iran

1WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, IR Iran

Archives of Clinical Infectious Diseases:Vol. 6, issue 3; 124-7

Article type:Brief Report

How to Cite:Vida FallahianAli EslamifarMohammad Amin FayazParisa MashayekhiPeyvand BiglariRabies Neutralizing Antibody Level in Immunosuppressed Patients After Receive of Rabies Post-Exposure Prophylaxis.Arch Clin Infect Dis.6(3):124-7.

Abstract

Introduction:

Rabies is a fatal disease and has a threatening risk for the public health. Immunosuppression is related to a wide variety of diseases. It is recommended that immunosuppressed patients receive the full post-exposure vaccination, concerning that the immune response may be inadequate. The aim of this study is to determine the level of rabies neutralizing antibody in immunosuppressed patients after receiving rabies post-exposure prophylaxis. Consequently we assess the efficiency of antibody level in immunosuppressed patients admitted at Pasteur Institute of Iran.

Results:

Twenty two cases were evaluated. The Immunosuppressed state was related to cancer (in 8 cases), 4 cases of hematologic disorders, 6 cases of autoimmune disease, and 4 cases of chronic renal failure or kidney transplant. Mean age of 46.45 21.5 year. All cases received HRIG serum (human rabies immunoglobulin) plus PVRV (Purified Vero cell rabies vaccine). The level of rabies neutralizing antibody was checked two weeks after the last dose of vaccine. Mean level of rabies neutralizing antibody was 12.07 6.72 IU/ml. All cases achieved minimum protective level of antibody which is ? 0.5 IU/ml. The amount of the antibody level had no relation to age or kind of immunosuppressive disease of patients.

Conclusion:

It is recommended that Rabies-exposed immunosuppressed patients receive rabies post exposure prophylaxes. We have to be cautious about the cases who have not achieved the appropriate level of rabies antibody.

Keywords

Post-exposure rabies prophylaxis

Immunosuppressed patients

Rabies neutralizing antibody

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