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Archives of Clinical Infectious Diseases

Infectious Diseases and Tropical Medicine Research Center, SBUMS

e-ISSN 2345-2641
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Relationship Between Brucella Immunocomplex and Glomerulopathies

Authors

Ebtehaj Pishva1,*, Mansour Salehi2, Manoochehr Gharavi1
1Department of Bacteriology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
2Department of Genetic and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, IR Iran
*Corresponding Author: Department of Bacteriology, Faculty of Medicine, Isfahan University of Medical Sciences, Hezar Jarib St., Isfahan, IR Iran. Email:, [email protected]. Email: [email protected]
Archives of Clinical Infectious Diseases:Vol. 3, issue 3; 127-132
Published online:Jul 31, 2008
Article type:Research Article
How to Cite:Pishva E, Salehi M, Gharavi M. Relationship Between Brucella Immunocomplex and Glomerulopathies. Arch Clin Infect Dis. 2008;3(3):. doi:

Abstract

Background:

Brucellosis is a zoonotic disease with a very wide spectrum of clinical findings. Brucellosis is about 10 times more prevalent in patients with renal failure (dialysis patients) compared to population background. Precipitation of immunocomplexes produced by brucellosis is important in causing glomerulonephritis. Because the hallmark of glomerular diseases is abnormal protein loss in the urine we have decided to study proteinuria in brucellosis immunocomplex. The aim of this study was to evaluate probable relationship between brucellosis and glomerulonephritis.

Patients and Methods:

This cross sectional study, performed on 200 patients with a history of the disease for about 1 year, diagnosed as having chronic brucellosis. The diagnosis was confirmed in 150 patients and by applying Brucella Standard Agglutination Test (SAT) and 2-mercaptoethanol test (2-ME). Titers of IgG/IgM and IgG/IgA in two groups of "with proteinuria" and "without proteinuria" was measured.

Results:

Both SAT and 2-ME tests test demonstrated that proteinuria increases with rising antibodies titers. In SAT, titer 1/160 was the most frequent, observed in 44% of the patients. In 2-ME test 1/40 titer was observed in 44% of the patients and was the most frequent.

Conclusion:

Our results clearly demonstrated that in both chronic and acute patients, proteinuria increases with rising IgG/IgA and IgM/IgG titers. Therefore brucellosis can cause nephropathy but chronic or untreated brucellosis is more important because it can permanently damage kidney.

KeywordsBrucellosisImmune complexGlomerulonephritisNephropathy

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Copyright

© 2008, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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