Human Papillomavirus (HPV) Detection in Biopsies from Cervical Cancer Patients; A Population–Based Study from Iran

Mohammad Niakan; Fariba Yarandi; Maryam Entezar

Archives of Clinical Infectious Diseases

Infectious Diseases and Tropical Medicine Research Center, SBUMS

Current Issue All Issues In Press Accepted Manuscripts Search

Indexing and Listing Sources Reviewer and AE Registration Form Editors & Boards Journal Information Journal Metrics Contact Us Open Peer Review (OPR)Publication Ethics and Malpractice Statement Support

APC

Authors Guide Submit Manuscript

Human Papillomavirus (HPV) Detection in Biopsies from Cervical Cancer Patients; A Population–Based Study from Iran

Author(s):

Mohammad Niakan^1,*,

Fariba Yarandi²,

Maryam Entezar²

1Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, IR Iran

2Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, IR Iran

Archives of Clinical Infectious Diseases:Vol. 4, issue 1; e93397

Published online:Jan 30, 2009

Article type:Brief Report

Received:May 12, 2019

Accepted:Jul 22, 2008

How to Cite:Mohammad NiakanFariba YarandiMaryam EntezarHuman Papillomavirus (HPV) Detection in Biopsies from Cervical Cancer Patients; A Population–Based Study from Iran.Arch Clin Infect Dis.4(1):e93397.

Abstract

Background: Human papillomavirus (HPV) is associated with various benign and malignant lesions including genital condyloma and anogenital cancer. The presence of HPV-DNA was studied in archival biopsies of high- and intermediate-risk lesions for cervical carcinoma in women referred to Mirza hospital in Tehran.

Patients and methods: Totally, 105 Iranian archived biopsies collected during February and November 2006. HPVDNA was isolated from the biopsies and detected by means of consensus polymerase chain reaction (PCR) detecting a broad spectrum of genital HPV types.

Results: Totally, 26 samples (24.7%) were positive for oncogenic HPV-DNA. Risk of HPV infection was significantly higher in biopsies obtained from patients with confirmed squamous cell carcinoma (SCC) who started sexual activity more recently (≤4 years ago) when compared with those who started earlier (≥10 years ago). HPV-16 was more frequently detected in biopsies of younger women.

Conclusion: HPV was more frequently detected in young women. Our data confirm the usefulness of this method for detection of HPV in archival biopsies.

Keywords

Human papillomavirus (HPV)

Cervical cancer

Archival biopsy samples

Polymerase chain reaction (PCR)

References

1.
The references are available in PDF file.

comments