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Effect of Acute Maximal Exercise on Circulating Levels of Interleukin-12 during Ramadan Fasting

Author(s):
Salma AbedelmalekSalma Abedelmalek2, Nizar SouissiNizar Souissi3,*, Akimoto TakayukiAkimoto Takayuki4, Sami HadoukSami Hadouk5, Zouhair TabkaZouhair Tabka2
2Department of Physiology, Sousse Faculty of Medicine, Tunisia
3Research Unit, Evaluation, Sport, Health National Centre of Medicine and Science in Sport, Tunisia
4Laboratory of Regenerative Medical Engineering, Centre for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Japan
5Department of Immunology, Sfax Faculty of Medicine, Tunisia


Asian Journal of Sports Medicine:Vol. 2, issue 3; 154-160
Published online:Aug 31, 2011
Article type:Research Article
Received:Nov 05, 2010
Accepted:Apr 16, 2011
How to Cite:Salma AbedelmalekNizar SouissiAkimoto TakayukiSami HadoukZouhair TabkaEffect of Acute Maximal Exercise on Circulating Levels of Interleukin-12 during Ramadan Fasting.Asian J Sports Med.2(3):34751.https://doi.org/10.5812/asjsm.34751.

Abstract

Purpose:

The purpose of this study was to examine the effects of Ramadan fasting on circulating levels of interleukin-12 (IL-12) after a brief maximal exercise.

Methods:

Nine subjects performed a Wingate test on three different occasions: (i) the first week of Ramadan (1WR), (ii) the fourth week of Ramadan (4WR), and (iii) three weeks after Ramadan (AR). Blood samples were taken before, immediately and 60 min after the exercise. Plasma concentrations of IL-12 were measured using enzyme-linked immunosorbent assay. Variance analysis revealed no significant effect of Ramadan on Ppeak and Pmean during the three testing periods.

Results:

Considering the effect of Ramadan on plasma concentrations of IL-12, analysis of the variance revealed a significant Ramadan effect (F(2,16)=66.27; P < 0.001) as well as a significant time effect (F(2,16)= 120.66; P < 0.001). However, no significant (Ramadan time) of test interaction (F(4,32)=2.40; P>0.05). For all measures, IL-12 levels were lower during 1WR and 4WR in comparison with AR (P < 0.05). Considering the exercise effects, IL-12 levels measured immediately after the exercise were significantly higher than those measured before and at 60 minutes after the exercise (P < 0.001).

Conclusions:

These results suggest that an acute intense exercise-induced IL-12 response is modified by daytime fasting and modifications in sleep schedule during Ramadan.

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