Abstract
Purpose:
It is well known that the effects of exercise training gives inter individual differences which might be due to genetic diversity. This study aims to explore the probable relation between angiotensin converting enzyme (ACE) alleles and physical fitness parameters in elite athletes.Methods:
Twenty-nine national level Indian Army Triathletes who volunteered for the study were taken as subjects and 101 healthy age matched control group subjects were taken for comparison of genotype frequencies. The following parameters were checked in triathletes: blood pressure, body mass index, VO2 max, muscular endurance, flexibility and power. DNA was extracted from blood using standard phenol-chloroform method. Genotyping was done using PCR specific for ACE (I/D) polymorphism, followed by agarose gel electrophoresis method. Variation of the parameters among different genotypes was compared. Genotype frequencies of triathletes were compared with the control group as well.Results:
No difference was observed between fitness parameters of three genotype groups triathletes, while the frequency of I allele was found to be very high in triathletes compared with the control group.Conclusion:
It can be concluded that there might be a positive association between I allele of ACE gene and endurance.Keywords
ACE Polymorphism Genetic Angiotensin converting enzyme Physical fitness Genotyping
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© 2010, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.