The Effect of Two-Week L-Carnitine Supplementation on Exercise –Induced Oxidative Stress and Muscle Damage

Khadijeh Parandak; Hamid Arazi; Faegheh Khoshkhahesh; Babak  Nakhostin Roohi

Asian Journal of Sports Medicine

Sports Medicine Research Center, TUMS

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The Effect of Two-Week L-Carnitine Supplementation on Exercise –Induced Oxidative Stress and Muscle Damage

Author(s):

Khadijeh Parandak¹,

Hamid Arazi²,

Faegheh Khoshkhahesh³,

Babak Nakhostin Roohi^3,*

1Rasht Branch, Islamic Azad University, Rasht, Iran

2Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran

3Department of Exercise Physiology, Ardabil Branch, Islamic Azad University, Ardabil, Iran

Asian Journal of Sports Medicine:Vol. 5, issue 2; e93515

Published online:Mar 01, 2014

Article type:Research Article

Received:May 13, 2019

Accepted:Feb 04, 2014

How to Cite:Khadijeh ParandakHamid AraziFaegheh KhoshkhaheshBabak Nakhostin RoohiThe Effect of Two-Week L-Carnitine Supplementation on Exercise –Induced Oxidative Stress and Muscle Damage.Asian J Sports Med.5(2):e93515.

Abstract

Purpose: This study was conducted to assess the effect of Two-week L-carnitine supplementation on known markers of oxidative stress and muscle damage following acute bouts of exercise in active healthy young men.

Methods: Twenty-one active healthy men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: L-carnitine (C group; n=10) and placebo group (P group; n=11). They arrived at the laboratory after overnight fasting. A baseline blood sample was taken. Afterwards, subjects consumed either L-carnitine (2 capsules containing totally 2000 mg L-carnitine) or placebo (2 capsules containing totally 2000 mg lactose) daily for 14 days. On the day of the test, participants attended the athletics arena after overnight fasting. Then, participants were asked to run 14 km on the track at their highest ability. Blood samples were taken immediately, 2, and 24 hours after exercise. Plasma total antioxidant capacity (TAC), malondialdehyde (MDA) as thiobarbituric acid-reactive substance (TBARS) as a marker of lipid peroxidation, creatine kinase (CK) and lactate dehydrogenase (LDH) as markers of muscle damage were measured.

Results: TAC increased significantly 14 days after supplementation and 24h after exercise in C group compared with P group (P<0.05). Serum MDA-TBARS, CK, and LDH were significantly lower 24h after exercise in C group compared with P group (P<0.05).

Conclusions: These results suggest that two-week daily oral supplementation of L-carnitine has alleviating effects on lipid peroxidation and muscle damage markers following an acute bout of exercise in active healthy young men.

Keywords

Lipid Peroxidation

Antioxidants

Thiobarbituric Acid-Reactive Substance

Creatine Kinase

Oxidative Stress

References

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The references are available in PDF file.

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