Metabolic Syndrome and Mitochondrial Transcription Factor A


avatar Marijana Tadic 1 , * , avatar Cesare Cuspidi 2

University Hospital Center “Dr. Dragisa Misovic”, Belgrade, Serbia
Italian Auxologico Institute, Clinical Research Unit, University of Milan-Bicocca, Meda, Italy

how to cite: Tadic M, Cuspidi C. Metabolic Syndrome and Mitochondrial Transcription Factor A. Gene Cell Tissue. 2014;1(2):e20664.


  • 1.

    Kusminski CM, Scherer PE. Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol Metab. 2012;23(9):435-43. [PubMed ID: 22784416].

  • 2.

    Choi YS, Kim S, Pak YK. Mitochondrial transcription factor A (mtTFA) and diabetes. Diabetes Res Clin P. 2001;54:S3-9.

  • 3.

    Vernochet C, McDonald ME, Farmer SR. Brown adipose tissue: a promising target to combat obesity. Drug News Perspect. 2010;23(7):409-17. [PubMed ID: 20862392].

  • 4.

    Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, et al. Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metab. 2012;16(6):765-76. [PubMed ID: 23168219].

  • 5.

    Santos JM, Kowluru RA. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Diabetes Metab Res Rev. 2013;29(3):204-13. [PubMed ID: 23255365].

  • 6.

    Wang CH, Wang CC, Huang HC, Wei YH. Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes. FEBS J. 2013;280(4):1039-50. [PubMed ID: 23253816].

  • 7.

    Holmstrom MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM. Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab. 2012;302(6):E731-9. [PubMed ID: 22252943].

  • 8.

    Hashemi M, Rezaei H, Ali Kaykhaei M, Taheri M. Association of the Promoter Methylation of Mitochondrial Transcription Factor A With Susceptibility to Metabolic Syndrome. Gene Cell Tissue. 2014;1(1). e18308.

  • 9.

    Ikeuchi M, Matsusaka H, Kang D, Matsushima S, Ide T, Kubota T, et al. Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction. Circulation. 2005;112(5):683-90. [PubMed ID: 16043643].

  • 10.

    Colom B, Oliver J, Garcia-Palmer FJ. Sexual Dimorphism in the Alterations of Cardiac Muscle Mitochondrial Bioenergetics Associated to the Ageing Process. J Gerontol A Biol Sci Med Sci. 2014:[Epub ahead of print]. [PubMed ID: 24682352].