Can Vitamin D Prevent Breast Cancer?


avatar Maryam Moossavi 1 , 2 , avatar Milad Mohammadoo-Khorasani ORCID 3 , *

Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
Department of Molecular Medicine, Birjand University of Medical Sciences, Birjand, Iran
Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran

how to cite: Moossavi M, Mohammadoo-Khorasani M. Can Vitamin D Prevent Breast Cancer?. Gene Cell Tissue. 2018;5(1):e74216.


  • 1.

    Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014;14(5):342-57. [PubMed ID: 24705652].

  • 2.

    Klampfer L. Vitamin D and colon cancer. World J Gastrointest Oncol. 2014;6(11):430-7. [PubMed ID: 25400874]. [PubMed Central ID: PMC4229786].

  • 3.

    Jacobs ET, Kohler LN, Kunihiro AG, Jurutka PW. Vitamin D and Colorectal, Breast, and Prostate Cancers: A Review of the Epidemiological Evidence. J Cancer. 2016;7(3):232-40. [PubMed ID: 26918035]. [PubMed Central ID: PMC4747876].

  • 4.

    Al-Musharaf S, Fouda MA, Turkestani IZ, Al-Ajlan A, Sabico S, Alnaami AM, et al. Vitamin D Deficiency Prevalence and Predictors in Early Pregnancy among Arab Women. Nutrients. 2018;10(4). [PubMed ID: 29662044]. [PubMed Central ID: PMC5946274].

  • 5.

    Narooie-Nejad M, Moossavi M, Torkamanzehi A, Moghtaderi A, Salimi S. Vitamin D Receptor Gene Polymorphism and the Risk of Multiple Sclerosis in South Eastern of Iran. J Mol Neurosci. 2015;56(3):572-6. [PubMed ID: 25854779].

  • 6.

    Stewart B, Wild CP. World cancer report 2014. NY: Health; 2017.

  • 7.

    Yao S, Kwan ML, Ergas IJ, Roh JM, Cheng TD, Hong CC, et al. Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival: A Case-Cohort Analysis in the Pathways Study. JAMA Oncol. 2017;3(3):351-7. [PubMed ID: 27832250]. [PubMed Central ID: PMC5473032].

  • 8.

    O'Brien KM, Sandler DP, Taylor JA, Weinberg CR. Serum Vitamin D and Risk of Breast Cancer within Five Years. Environ Health Perspect. 2017;125(7):77004. [PubMed ID: 28728134]. [PubMed Central ID: PMC5744694].

  • 9.

    Colston KW, Hansen CM. Mechanisms implicated in the growth regulatory effects of vitamin D in breast cancer. Endocr Relat Cancer. 2002;9(1):45-59. [PubMed ID: 11914182].

  • 10.

    Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat. 2010;121(2):469-77. [PubMed ID: 19851861].

  • 11.

    Ordonez-Mena JM, Schottker B, Fedirko V, Jenab M, Olsen A, Halkjaer J, et al. Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium. Eur J Epidemiol. 2016;31(3):311-23. [PubMed ID: 25977096].

  • 12.

    Stoll F, Akladios CY, Mathelin C. [Vitamin D and breast cancer: is there a link?]. Gynecol Obstet Fertil. 2013;41(4):242-50. [PubMed ID: 23562418].

  • 13.

    Bilinski K, Boyages J. Association between 25-hydroxyvitamin D concentration and breast cancer risk in an Australian population: an observational case-control study. Breast Cancer Res Treat. 2013;137(2):599-607. [PubMed ID: 23239153].

  • 14.

    Park S, Lee DH, Jeon JY, Ryu J, Kim S, Kim JY, et al. Serum 25-hydroxyvitamin D deficiency and increased risk of breast cancer among Korean women: a case-control study. Breast Cancer Res Treat. 2015;152(1):147-54. [PubMed ID: 26037255].

  • 15.

    Imtiaz S, Siddiqui N, Raza SA, Loya A, Muhammad A. Vitamin D deficiency in newly diagnosed breast cancer patients. Indian J Endocrinol Metab. 2012;16(3):409-13. [PubMed ID: 22629509]. [PubMed Central ID: PMC3354850].