The Role of Hypoxia in Normal Pregnancy and Pregnancy Complications


avatar Nadia Sheibak ORCID 1 , *

Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran

how to cite: Sheibak N. The Role of Hypoxia in Normal Pregnancy and Pregnancy Complications. Gene Cell Tissue. 2018;5(2):e80202.


  • 1.

    Zhao H, Jiang Y, Cao Q, Hou Y, Wang C. Role of integrin switch and transforming growth factor Beta 3 in hypoxia-induced invasion inhibition of human extravillous trophoblast cells. Biol Reprod. 2012;87(2):47. 1-7.

  • 2.

    Tuuli MG, Longtine MS, Nelson DM. Review: Oxygen and trophoblast biology--a source of controversy. Placenta. 2011;32 Suppl 2:S109-18. [PubMed ID: 21216006]. [PubMed Central ID: PMC3682830].

  • 3.

    Wakeland AK, Soncin F, Moretto-Zita M, Chang CW, Horii M, Pizzo D, et al. Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor-Dependent Manner. Am J Pathol. 2017;187(4):767-80. [PubMed ID: 28167044]. [PubMed Central ID: PMC5397702].

  • 4.

    Horii M, Li Y, Wakeland AK, Pizzo DP, Nelson KK, Sabatini K, et al. Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A. 2016;113(27):E3882-91. [PubMed ID: 27325764]. [PubMed Central ID: PMC4941448].

  • 5.

    Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest. 2000;105(5):577-87. [PubMed ID: 10712429]. [PubMed Central ID: PMC289179].

  • 6.

    Wallace AE, Fraser R, Cartwright JE. Extravillous trophoblast and decidual natural killer cells: a remodelling partnership. Hum Reprod Update. 2012;18(4):458-71. [PubMed ID: 22523109]. [PubMed Central ID: PMC3373213].

  • 7.

    Heidari Z, Mahmoudzadeh-Sagheb H, Sheibak N. Quantitative changes of extravillous trophoblast cells in heavy smoker mothers compared with healthy controls. Reprod Fertil Dev. 2018;30(2):409-14. [PubMed ID: 28723341].

  • 8.

    Heidari Z, Mahmoudzadeh-Sagheb H, Sheibak N. Placenta structural changes in heavy smoking mothers: a stereological aspect. Curr Med Res Opin. 2018:1-5. [PubMed ID: 29469634].

  • 9.

    Heidari Z, Mahmoudzadeh-Sagheb H, Sheibak N, Nourzaei N. Quantitative changes of extravillous trophoblast cells in placentas of systemic lupus erythematosus patients. J Obstet Gynaecol. 2017;37(6):746-51. [PubMed ID: 28399698].

  • 10.

    Fazli M, Ghorbian S. Association Study of Non-Coding RNA miR-499 and miR196a2 Gene Polymorphisms with the Risk of Idiopathic Recurrent Pregnancy Loss. Gene, Cell and Tissue. 2018;In Press(In Press).