Biological Functions of Exosomes in the Liver in Health and Disease

authors:

avatar Abbas Ali Imani Fooladi ORCID 1 , * , avatar Hamideh Mahmoodzadeh Hosseini 1

Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran

how to cite: Imani Fooladi A A, Mahmoodzadeh Hosseini H. Biological Functions of Exosomes in the Liver in Health and Disease. Hepat Mon. 2014;14(5):e13514. https://doi.org/10.5812/hepatmon.13514.

Acknowledgements

References

  • 1.

    Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008;48(1):322-35. [PubMed ID: 18506843]. https://doi.org/10.1002/hep.22306.

  • 2.

    Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73(10):1907-20. [PubMed ID: 20601276]. https://doi.org/10.1016/j.jprot.2010.06.006.

  • 3.

    Hosseini HM, Fooladi AA, Nourani MR, Ghanezadeh F. The role of exosomes in infectious diseases. Inflamm Allergy Drug Targets. 2013;12(1):29-37. [PubMed ID: 23441990].

  • 4.

    Masyuk AI, Masyuk TV, Larusso NF. Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases. J Hepatol. 2013;59(3):621-5. [PubMed ID: 23557871]. https://doi.org/10.1016/j.jhep.2013.03.028.

  • 5.

    Conde-Vancells J, Gonzalez E, Lu SC, Mato JM, Falcon-Perez JM. Overview of extracellular microvesicles in drug metabolism. Expert Opin Drug Metab Toxicol. 2010;6(5):543-54. [PubMed ID: 20192903]. https://doi.org/10.1517/17425251003614766.

  • 6.

    Hennessy M, Spiers JP. A primer on the mechanics of P-glycoprotein the multidrug transporter. Pharmacol Res. 2007;55(1):1-15. [PubMed ID: 17095241]. https://doi.org/10.1016/j.phrs.2006.10.007.

  • 7.

    Masyuk AI, Huang BQ, Ward CJ, Gradilone SA, Banales JM, Masyuk TV, et al. Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia. Am J Physiol Gastrointest Liver Physiol. 2010;299(4):G990-9. [PubMed ID: 20634433]. https://doi.org/10.1152/ajpgi.00093.2010.

  • 8.

    Welker MW, Reichert D, Susser S, Sarrazin C, Martinez Y, Herrmann E, et al. Soluble serum CD81 is elevated in patients with chronic hepatitis C and correlates with alanine aminotransferase serum activity. PLoS One. 2012;7(2). [PubMed ID: 22355327]. https://doi.org/10.1371/journal.pone.0030796.

  • 9.

    Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, Masurier C, et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med. 2001;7(3):297-303. [PubMed ID: 11231627]. https://doi.org/10.1038/85438.

  • 10.

    Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, Ward J, et al. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology. 2012;56(5):1946-57. [PubMed ID: 22684891]. https://doi.org/10.1002/hep.25873.