Severe Mononeuritis Multiplex Associated with Peginterferon-Ribavirin Therapy of Chronic Hepatitis C

authors:

avatar Darko Nozic 1 , * , avatar Branislav Antic 2 , avatar Vasna Begovic 2 , avatar Gorana Stamenkovic 2

Clinic of Infectious and Tropical Diseases, Military Medical Academy, darkonozic@yahoo.com, Serbia
Clinic of Neurosurgery, Military Medical Academy, Serbia
Hepatitis Monthly: Vol.9, issue 1; 70-72
article type: Case Report
received: October 14, 2008
accepted: January 3, 2009
DOI: https://doi.org/10.5812/cardiovascmed.4498

how to cite: Nozic D, Antic B, Begovic V, Stamenkovic G. Severe Mononeuritis Multiplex Associated with Peginterferon-Ribavirin Therapy of Chronic Hepatitis C. Hepat Mon. 2009;9(1): 70-72. https://doi.org/10.5812/cardiovascmed.4498.

Abstract

Vasculitis is a common extrahepatic manifestation of chronic hepatitis C virus infection and could be either associatedwith cryoglobulinemia or not.

The mechanism of peripheral neuropathy seems to be vasculitic in both cryoglobulinemic and non-cryoglobulinemic patients. Antiviral therapy with peginterferon and ribavirin usually improves symptoms of virus-induced neuropathy. Herein, we reported on a rare case of hard mononeuritis multiplex triggered by antiviral therapy in a patient without neurological symptoms before the treatment.

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