E-Selectin Gene Polymorphisms in Iranian Chronic Hepatitis B Patients

3Professor of Gastroenterology and Hepatology, Baqiyatallah Research Center for Gastroenterology and Liver Disease (BRCGL), Baqiyatallah University of Medical Sciences, editor@hepmon.ir, Tehran, IR.Iran

Hepatitis Monthly:Vol. 7, issue 4; 211-216

Published online:Dec 31, 2007

Article type:Research Article

Received:Nov 17, 2007

Accepted:Jan 05, 2008

How to Cite:Hajilooi M, Alizadeh A M, Ranjbar M, Fallahian F, Alavian S M. E-Selectin Gene Polymorphisms in Iranian Chronic Hepatitis B Patients.Hepat Mon.2007;7(4):211-216.

Abstract

Background and Aims: The aim of this study is to detect the substitutions Ser128Arg (A128C) and Leu554Phe (T554C) which responsible for E-selectin polymorphisms in patients with chronic hepatitis B and healthy controls. We investigated association of the Ser128Arg, Leu554Phe gene polymorphisms in the E-selectin gene as prototypical inflammatory molecules for susceptibility to chronic hepatitis B.

Methods: Sixty-three patients with chronic hepatitis B virus infection and 150 healthy subjects were recruited sequentially as they presented to clinic. Genomic DNA was isolated from anti-coagulated peripheral blood Buffy coat using Miller's salting-out method. The presence of the E-selectin gene polymorphisms was determined by using polymerase chain reaction amplification refractory mutation system (ARMS).

Results: Distribution of E-selectin 128 (A⁺C^-, A⁺C⁺, A^-C⁺) genotypes and E-selectin genotype 554 (C⁺T^-, T⁺C^-, C⁺T⁺) genotypes were not statistically significant different in chronic hepatitis B patients and controls by Chi-square test (P=0.41 & 0.96, respectively). Also, Two groups had not statistically significant difference in distribution of frequencies of allele 128 A by Chi-square test (P=0.41), 128 C (P=0.15), allele 554 C (P=0.85), and allele 554 T (P=0.76). Carrying allele 128 A (OR=0.587, 95% CI=0.162-2.124), 128 C (OR=1.526, 95% CI=0.849-2.745), 554 C (OR=1.245, 95% CI=0.128-12.089), and allele 554 T (OR=0.880, 95% CI=0.384-2.014) were not risk factors for susceptibility to chronic hepatitis B infection.

Conclusions: Carrying E-selectin gene polymorphisms of Ser128Arg and Leu554Phe are not risk factors for susceptibility to chronic hepatitis B.

Keywords

E-Selectin Gene

Chronic Hepatitis B

Gene Polymorphisms

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Author(s):

Mehrdad Hajilooi:[PubMed][Scholar]
Amir-Houshang Alizadeh:[PubMed][Scholar]
Mitra Ranjbar:[PubMed][Scholar]
Farahnaz Fallahian:[PubMed][Scholar]
Seyed Alavian:[PubMed][Scholar]

Official Journal of Research Center for Gastroenterology and Liver Diseases

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E-Selectin Gene Polymorphisms in Iranian Chronic Hepatitis B Patients

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