Non-alcoholic steatohepatitis: An update in pathophysiology, diagnosis and therapy

authors:

avatar Hossein Khedmat 1 , * , avatar Saeed Taheri 2

Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Khedmat.h@gmail.com, IR.Iran
Dr. Taheri Medical Research Group, IR.Iran
Hepatitis Monthly: Vol.11, issue 2; 74-85
article type: Review Article
received: May 23, 2010
accepted: August 27, 2010

How To Cite Khedmat H, Taheri S. Non-alcoholic steatohepatitis: An update in pathophysiology, diagnosis and therapy. Hepat Mon. 2011;11(2): 74-85. 

Abstract

Non-alcoholic steatohepatitis (NASH), first described by Ludwig et al, in 1980, is a stage in the wide spectrum of non-alcoholic fatty liver diseases (NAFLDs) and one of the leading causes of chronic liver disease. Several scientists have tried to more distinctly discover and describe different aspects of NASH. In contrast with its counterpart in the NAFLDs-the NAFL-NASH consists of inflammation as well as necrosis in the liver tissue resulting in a poor outcome. NASH is also a known etiology for cryptogenic liver cirrhosis. Evidence suggests that cirrhosis developing due to NASH have a relatively worse outcome compared to that of hepatitis C-related cirrhosis. In this review article, we try to review and present all relevant articles about NASH.

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