https://doi.org/10.5812/hepatmon.818

Hepatitis C Virus Cryoglobulinemia and Non-Hodgkin Lymphoma

authors:

avatar Zohreh Jadali 1 , * , avatar Zohreh Jadali 1 , *

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran
Corresponding Authors:
Hepatitis Monthly: Vol.12, issue 2; 85-91
published online: January 31, 2012
article type: Review Article
received: December 17, 2011
accepted: January 20, 2012

How To Cite Jadali Z, Jadali Z. Hepatitis C Virus Cryoglobulinemia and Non-Hodgkin Lymphoma. Hepat Mon. 2012;12(2): 85-91. https://doi.org/10.5812/hepatmon.818.

Abstract

Context:

On the strength of epidemiological data,biological studies, and clinical findings, hepatitis C virus appears to be involved in the pathogenesis of a proportion of patients with non-Hodgkin lymphoma and cryoglobulinemia.

Objectives:

The aim of this paper is to review the published literature focused on the current knowledge concerning hepatitis C virus and its potential role in the production of non-Hodgkin lymphoma and cryoglobulinemia in susceptible individuals.

Evidence Acquisition:

In this review, databases such as pubMed, embase, ISI, and Iranian databases including Iranmedex, and SID were searched.

Results:

The results of this review indicate that HCV infection may be a likely cause of various B cell dysregulation disorders such as non-Hodgkin lymphoma and cryoglobulinemia.

Conclusion:

Based on current findings, it has been hypothesized that NHL and cryoglobulinemia in HCV infection may have an immune-mediated pathogenesis. In HCV infected patients, we showed an elevated risk of these two diseases. These finding suggested a possible role for chronic hepatitis C in the pathogenesis of NHL and cryoglobulinemia.

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