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Background:
The impact of hepatitis B virus (HBV) vaccination campaigns on HBV epidemiology needs to be evaluated, in order to assess the long-term immunity offered by vaccines against HBV.
Hepatitis Monthly
Official Journal of Research Center for Gastroenterology and Liver Diseases
Long-Term Persistence of Seroprotection by Hepatitis B Vaccination in Healthcare Workers of Southern Italy
Author(s):
Giuseppe Grosso1, Antonio Mistretta1,*, Stefano Marventano1, Roberta Ferranti1, Luisa Mauro1, 
Rosario Cunsolo2, Lidia Proietti3, Mariano Malaguarnera41G.F. Ingrassia Department, Section of Hygiene and Public Health, University of Catania, anmist@unict.it, Italy
2Rosario Cunsolo, Vittorio Emanuele Hospital of Catania Health Direction, Italy
3Department of Internal Medicine and Systemic Diseases, University of Catania, Italy
4The Great Senescence Research Center, University of Catania, Ospedale Cannizzao, Italy
Published online:Sep 04, 2012
Article type:Research Article
Received:Nov 22, 2011
Accepted:Jul 28, 2012
How to Cite:Giuseppe GrossoAntonio MistrettaStefano MarventanoRoberta FerrantiLuisa MauroRosario CunsoloLidia ProiettiMariano Malaguarneraet al.Long-Term Persistence of Seroprotection by Hepatitis B Vaccination in Healthcare Workers of Southern Italy.Hepat Mon.12(9):6025.https://doi.org/10.5812/hepatmon.6025.
Abstract
Objectives:
To evaluate the current status of anti-HBV vaccine coverage among healthcare workers (HCWs) in Southern Italy, and to determine the long-term persistence of antibodies to hepatitis B surface antigens (anti-HBs) in such a cohort of subjects.
Patients and Methods:
A longitudinal, retrospective seroepidemiological survey was conducted among 451 HCWs, who were working at or visiting, the Occupational Health Department of a city hospital, in Catania, Italy, between January 1976 and December 2010.
Results:
At the 30-year follow-up (mean follow-up 10.15 5.96 years, range 0.74-30), 261 HCWs had detectable anti-HBs titers indicating a persistence of seroprotection of 89.4% (out of 292 anti-HBs positive results, three months after vaccination). An inadequate vaccination schedule was the strongest predictor of antibody loss during follow-up (OR = 8.37 95% CI: 5.41-12.95, P < 0.001). A Kaplan-Maier survival curve revealed that the persistence of anti-HBs 30 years after vaccination, was 92.2% for high responders, while it was only 27.3% for low responders (P = 0.001).
Conclusions:
A good level of seroprotection persisted in 57.9% of the subjects after 30 years. Factors related to this immunization status confirmed the importance of vaccinating HCWs early in their careers and ensuring an adequate vaccination schedule. However, with particular reference to the low rate of hepatitis B vaccine coverage among HCWs in Southern Italy, the implementation of a new educational intervention as part of an active vaccination program is needed.
Copyright
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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