Logo

Serum Profile of T Helper 1 and T Helper 2 Cytokines in Hepatitis C Virus Infected Patients

Author(s):
Masoomeh SofianMasoomeh Sofian1, Arezoo AghakhaniArezoo Aghakhani2, Ali Asghar Asghar FaraziAli Asghar Asghar Farazi1, Mohammad BanifazlMohammad Banifazl3, Ali EslamifarAli Eslamifar2, Niloofar RashidiNiloofar Rashidi2, Akbar Khadem SadeghAkbar Khadem Sadegh2, Amitis RamezaniAmitis Ramezani2,*
1Tuberculosis and Pediatric Infectious Research Center (TPIRC), Arak University of Medical Sciences, IR Iran
2Clinical Research Department, Pasteur Institute of Iran, amitisramezani@hotmail.com, IR Iran
3Iranian Society for Support of Patients With Infectious Diseases, IR Iran


Hepatitis Monthly:Vol. 12, issue 12; 6156
Published online:Dec 29, 2012
Article type:Research Article
Received:May 20, 2012
Accepted:Jun 15, 2012
How to Cite:Masoomeh SofianArezoo AghakhaniAli Asghar Asghar FaraziMohammad BanifazlAli EslamifarNiloofar RashidiAkbar Khadem SadeghAmitis Ramezaniet al.Serum Profile of T Helper 1 and T Helper 2 Cytokines in Hepatitis C Virus Infected Patients.Hepat Mon.12(12):6156.https://doi.org/10.5812/hepatmon.6156.

Abstract

Background:

T-helper (Th) lymphocyte cytokine production may be important in the immune pathogenesis of hepatitis C virus (HCV) infections. Th1 cytokines such as; interleukin- 2 (IL-2), and interferon gamma (IFN-gamma) are necessary for host antiviral immune responses, while Th2 cytokines (IL-4, IL-10) can inhibit the development of these effector mechanisms.

Objectives:

The aim of the present study was to assess the serum profile of Th1 and Th2 cytokines in treated and non-treated HCV infected individuals.

Patients and Methods:

This study was carried out in 63 HCV infected patients (31 under treatment and 32 untreated) and 32 matched HCV-sero negative healthy subjects. Serum samples were checked with an enzyme-linked immune sorbent assay (ELISA) for IL-2, IL-4, IL-10 and IFN-gamma.

Results:

Levels of circulating IL-2, IL-4, IL-10 and IFN-gamma were significantly elevated in HCV patients versus normal controls (2 822.6 1 259.92 vs. 950.8 286.9 pg/mL; 1 987 900.69 vs. 895.91 332.33 pg/mL; 1 688.5 1 405.1 vs. 519.03 177.64 pg/mL and 1 501.9 1 298 vs. 264.66 71.59 pg/mL, respectively; P < 0.001). The serum levels of all cytokines were significantly lower in the patients under treatment than those of the untreated patients (P < 0.001).

Conclusions:

On the basis of our data, the simultaneous increase of Th1 and Th2 related cytokines may indicate that both Thl and Th2 cytokines are involved in the pathogenesis of HCV infections. Moreover, this activated T-cell response in HCV infected patients may be regulated by treatment.

Full Text

Full text is available in PDF

comments

Leave a comment here


Crossmark
Crossmark
Checking
Share on
Metrics

Purchasing Reprints

  • Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here (   https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.
Search Relations

Author(s):

Related Articles