S100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma

Claudia Maletzki; Peggy  Bodammer; Anne Breitrck; Claus  Kerkhoff

doi:10.5812/hepatmon.7240

Hepatitis Monthly

Official Journal of Research Center for Gastroenterology and Liver Diseases

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https://doi.org/10.5812/hepatmon.7240

S100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma

Author(s):

Claudia Maletzki¹,

Peggy Bodammer³,

Anne Breitrck⁴,

Claus Kerkhoff^4,*

1Department of General Surgery, Division of Molecular Oncology and Immunotherapy, University of Rostock, Germany

3Fraunhofer Institute for Cell Therapy and Immunology, Department of Immunology, AG Extracorporeal Immune Modulation (EXIM), Germany

4Department of Internal Medicine, Division of Nephrology, University of Rostock, [email protected], Germany

Hepatitis Monthly:Vol. 12, issue 10; 7240

Published online:Oct 12, 2012

Article type:Review Article

Received:Jun 02, 2012

Accepted:Jul 16, 2012

How to Cite:Claudia MaletzkiPeggy BodammerAnne BreitrckClaus KerkhoffS100 Proteins as Diagnostic and Prognostic Markers in Colorectal and Hepatocellular Carcinoma.Hepat Mon.12(10):7240.https://doi.org/10.5812/hepatmon.7240.

Abstract

Context:

Clinical and experimental studies have suggested a link between S100 gene expression and neoplastic disorders, however, the molecular mechanisms of this association are not well understood. The aim of this review was to conduct a comprehensive literature search in order to understand the possible underlying molecular mechanisms of this association. We also discuss their application as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma.

Evidence Acquisitions:

We searched Pubmed (NLM) and Web of Science (ISI Web of Knowledge).

Results:

S100 genes display a complex expression pattern in colorectal and hepatocel lular carcinoma. They are expressed in tumor and/or tumor stroma cells, and they exert both pro- and antitumorigenic actions. In view of this complexity, it becomes clear that S100 proteins might act as both friend and foe. The biological role of the S100 genes is predicted to depend on the relative contributions of the different cell types at specific stages of tumor progression.

Conclusions:

Further research is required in order to uncover the functional role of S100 genes in tumorigenesis. Answers to this issue are needed before we can more fully understand the clinical relevance of S100 protein expression within epithelial tumors, with regard to their potential applicability as biomarkers for diagnosis and therapy decisions.

Keywords

Biological Markers

Cell Transformation

Neoplastic

Matrix Metalloproteinases

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Search Relations

Author(s):

Claudia Maletzki:[PubMed][Scholar]
Peggy Bodammer:[PubMed][Scholar]
Anne Breitrck:[PubMed][Scholar]
Claus Kerkhoff:[PubMed][Scholar]