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Diagnostic Value of Ultrasound in Detection of Biliary Tract Complications After Liver Transplantation

Author(s):
Andrej PotthoffAndrej Potthoff1, Anreas  HahnAnreas Hahn2, Stefan KubickaStefan Kubicka1, Andrea  SchneiderAndrea Schneider1, Jochen  WedemeyerJochen Wedemeyer3, Juergen  KlempnauerJuergen Klempnauer4, Michael  MannsMichael Manns1, Michael GebelMichael Gebel1, Bita BoozariBita Boozari1,*
1Department of Gastroenterology, Hannover Medical School, bita.boozari@med.uni-tuebingen.de, Germany
2Department of Biometrics, Hannover Medical School, Germany
3Department of Internal Medicine, Klinikum Robert Koch Gehrden, Germany
4Department of Visceral and Transplant Surgery, Hannover Medical School, Germany

Hepatitis Monthly:Vol. 13, issue 1; 6003
Published online:Jan 20, 2013
Article type:Research Article
Received:Oct 27, 2011
Accepted:May 01, 2012
How to Cite:Potthoff A, Hahn A, Kubicka S, Schneider A, Wedemeyer J, et al. Diagnostic Value of Ultrasound in Detection of Biliary Tract Complications After Liver Transplantation.Hepat Mon.2013;13(1):6003.https://doi.org/10.5812/hepatmon.6003.

Abstract

Background:

Biliary complications are significant source of morbidity after liver transplantation (LT). Cholangiography is the gold standard for diagnosis and specification of biliary complications.

Objectives:

Detailed analyses of ultrasound (US) as a safe imaging method in this regard are still lacking. Therefore we analyzed systematically the diagnostic value of US in these patients.

Patients and Methods:

Retrospectively, 128 liver graft recipients and their clinical data were analyzed. All patients had a standardized US examination. The findings of US were compared to cholangiographic results in 42 patients. Following statistical analyses were performed: descriptive statistics, sensitivity, specificity, positive and negative predictive values (PPV, NPV).

Results:

42 patients had 54 different biliary complications (Anastomotic stenosis (AS) n = 33, ischemic type biliary lesions (ITBL) n = 18 and leakage n = 3). US detected n = 22/42 (52%) patients with biliary complications. The sensitivity, specificity, PPV and NPV of US were: 61%, 100%, 100%, 79% (95CI, 36-86%) for ITBL and 24%, 100, 100%, 31% (95CI, 9-46 %) for AS, respectively.

Conclusions:

US examination had no false positive rate. Therefore, it may be helpful as a first screening modality. But for the direct diagnosis of the biliary complication US is not sensitive enough.

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