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Background:
Biliary complications are significant source of morbidity after liver transplantation (LT). Cholangiography is the gold standard for diagnosis and specification of biliary complications.
Hepatitis Monthly
Official Journal of Research Center for Gastroenterology and Liver Diseases
Diagnostic Value of Ultrasound in Detection of Biliary Tract Complications After Liver Transplantation
Author(s):
Andrej Potthoff1, 
Anreas Hahn2, Stefan Kubicka1, Andrea Schneider1, Jochen Wedemeyer3, Juergen Klempnauer4, Michael Manns1, Michael Gebel1, Bita Boozari1,*1Department of Gastroenterology, Hannover Medical School, bita.boozari@med.uni-tuebingen.de, Germany
2Department of Biometrics, Hannover Medical School, Germany
3Department of Internal Medicine, Klinikum Robert Koch Gehrden, Germany
4Department of Visceral and Transplant Surgery, Hannover Medical School, Germany
Published online:Jan 20, 2013
Article type:Research Article
Received:Oct 27, 2011
Accepted:May 01, 2012
How to Cite:Andrej PotthoffAnreas HahnStefan KubickaAndrea SchneiderJochen WedemeyerJuergen KlempnauerMichael MannsMichael GebelBita Boozariet al.Diagnostic Value of Ultrasound in Detection of Biliary Tract Complications After Liver Transplantation.Hepat Mon.13(1):6003.https://doi.org/10.5812/hepatmon.6003.
Abstract
Objectives:
Detailed analyses of ultrasound (US) as a safe imaging method in this regard are still lacking. Therefore we analyzed systematically the diagnostic value of US in these patients.
Patients and Methods:
Retrospectively, 128 liver graft recipients and their clinical data were analyzed. All patients had a standardized US examination. The findings of US were compared to cholangiographic results in 42 patients. Following statistical analyses were performed: descriptive statistics, sensitivity, specificity, positive and negative predictive values (PPV, NPV).
Results:
42 patients had 54 different biliary complications (Anastomotic stenosis (AS) n = 33, ischemic type biliary lesions (ITBL) n = 18 and leakage n = 3). US detected n = 22/42 (52%) patients with biliary complications. The sensitivity, specificity, PPV and NPV of US were: 61%, 100%, 100%, 79% (95CI, 36-86%) for ITBL and 24%, 100, 100%, 31% (95CI, 9-46 %) for AS, respectively.
Conclusions:
US examination had no false positive rate. Therefore, it may be helpful as a first screening modality. But for the direct diagnosis of the biliary complication US is not sensitive enough.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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