Full Text
Full text is available in PDF
Background:
HBV infection is a serious public health problem worldwide, which can contribute to the incidence of chronic hepatitis B (CHB), cirrhosis, and hepatocellular carcinoma (HCC).
Hepatitis Monthly
Official Journal of Research Center for Gastroenterology and Liver Diseases
Adiponectin and Its Receptors in Chronic Hepatitis B Patients With Steatosis in China
Author(s):
1Department of Ultrasound, Air Force General Hospital of PLA, Beijing, China
8Daping Hospital,Third Military Medical University, Chongqing, China
3Department of General Surgery, the Second People's Hospital of Guangdong Province, Guangzhou, China
4Department of Cardiology, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China
5Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xian, China
6International Mongolian Hospital, Hohhot of Inner Mongolia, Hohhot, China
7Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China
Corresponding Authors:
Published online:Apr 18, 2013
Article type:Research Article
Received:May 22, 2012
Accepted:Jan 30, 2013
How to Cite:Di WuHongqi LiGuoan XiangLiwei ZhangLihong LiYongmei CaoJinqian Zhanget al.Adiponectin and Its Receptors in Chronic Hepatitis B Patients With Steatosis in China.Hepat Mon.2013;13(4):6065.https://doi.org/10.5812/hepatmon.6065.
Abstract
Objectives:
In the present report, we assessed the association between adiponectin, its receptors and hepatic steatosis, fibrosis, and inflammation with hepatitis B virus.
Patients and Methods:
Liver biopsies from 89 patients with untreated chronic hepatitis B (34 steatosis vs. 55 without steatosis) were analyzed; liver biopsies from 50 healthy adults were used as control. The liver biopsies were subjected to routine histological examination, and stained immunohistochemically for adiponectin and adiponectin receptor2 (adipoR2).
Results:
The two groups were found to be comparable with respect to demographic, biochemical, metabolic, histological, and viral characteristics. BMI, ?-GT, FPG, insulin, and insulin sensitivity estimated by the HOMA index were significantly higher in patients with steatosis. The viral load of HBV and HBeAg positivity was higher in patients with steatosis than those without steatosis. High serum adiponectin levels were significantly correlated with abnormal serum ALT level (vs. normal ALT, P = 0.000), and HBV genotype C (vs. genotype B, P = 0.018). In patients with chronic HBV, the insulin sensitizing adipokine adiponectin, and its receptor AdipoR2were associated with steatosis. While adiponectin may becorrelated with inflammation, adiponectin, and its receptors were not associated with viral factors.
Conclusions:
Our results suggest that the role of adiponectin might be impaired in chronic hepatitis B with steatosis. Reduced hepatic expression of adiponectin and adipoR2 might be of pathophysiological relevance in CHB patients with steatosis. These findings indicated that reduced liver adiponectin expression may play an important role in the pathogenesis, and progression of CHB patients with steatosis. However, hepatic expression of adiponectin, and adipoR2 was not associated with various measures of HBV infection.
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
comments
Leave a comment here
Crossmark
Checking
Comments
Number of Comments:0Cited by
Purchasing Reprints
- Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.
Search Relations
Author(s):
Related Articles